Glucocorticoid receptor-αD1 modulates stress and inflammation

糖皮质激素受体-αD1 调节压力和炎症

• 批准号: DP230100379
• 负责人: Prof Vicki Clifton
• 金额: $ 33.74万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-03-30 至 2026-03-29
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100379
• 关键词: Glucocorticoid; receptor; D1; modulates; stress

Environmental stressors in mammalian pregnancy often cause inflammation in the mother which has an adverse effect on the fetus and its survival. The current grant aims to examine the mechanism by which stress and inflammation coexist in pregnancy because stress hormones normally exert anti-inflammatory actions. Contrary to convention, a new glucocorticoid receptor (GR), GRalpha D1, is linked to increasing inflammation. Using innovative molecular biology approaches, GRalphaD1's function will be examined to provide a deeper understanding of how stress regulates inflammation in animal reproduction. The project aims to enhance interdisciplinary collaborations with expected benefits including a paradigm shift in our knowledge in this field.

哺乳动物妊娠期的环境应激源常引起母体炎症，对胎儿及其存活有不利影响。目前的拨款旨在研究怀孕期间压力和炎症共存的机制，因为压力激素通常发挥抗炎作用。与常规相反，一种新的糖皮质激素受体（GR） grα D1与炎症增加有关。利用创新的分子生物学方法，GRalphaD1的功能将被研究，以更深入地了解应激如何调节动物繁殖中的炎症。该项目旨在加强跨学科合作，并带来预期的好处，包括我们在该领域知识的范式转变。