Multi-User Triple Quadrupole Electrospray Mass Spectrometer

多用户三重四极杆电喷雾质谱仪

• 批准号: 9115824
• 负责人: John Crabb
• 金额: --
• 依托单位: W. Alton Jones Cell Science Center
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-15 至 1995-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9115824&HistoricalAwards=false
• 关键词: Multi; User; Triple; Quadrupole; Electrospray

This proposal requests funds for the purchase of an electrospray triple-quadrupole mass spectrometer with on line HPLC and tandem mass spectrometry capability. It is planned that the instrument will serve primarily by nine user groups at the W. Alton Jones Cell Science Center. A broad range of independently supported studies are ongoing and all require the requested instrumentation. Most of the projects are directed at analysis of peptides and proteins and the proposed instrument will be located and operated within the institutional share Protein Chemistry Facility. The instrument will provide the user groups with ready access for the first time to low to sub-picomole level accurate mass spectrometric analyses of peptides and proteins covering a relatively broad mass range. There currently are no mass spectrometry instruments at the Cell Science Center. Mass spectrometry has become an indispensable tool for peptide and protein structure- function studies and is essential for satisfactory progress in the ongoing and future biological research at the W. Alton Jones Cell Science Center.

本提案要求提供资金，用于购买一台具有在线高效液相色谱和串联质谱能力的电喷雾三重四极质谱仪。根据计划，该仪器将主要由W.奥尔顿·琼斯细胞科学中心一系列独立支持的研究正在进行中，所有研究都需要所要求的仪器。大多数项目都是针对肽和蛋白质的分析，拟议的仪器将位于机构共享的蛋白质化学设施内并在其中运行。该仪器将首次为用户群体提供对肽和蛋白质进行低至亚皮摩尔水平的精确质谱分析的便利，涵盖相对较宽的质量范围。细胞科学中心目前没有质谱仪。质谱已成为肽和蛋白质结构-功能研究中不可或缺的工具，对于正在进行的和未来的生物学研究取得令人满意的进展至关重要。奥尔顿·琼斯细胞科学中心