U.S.-Poland Biophysics Research on Design of Peptide Mimetics

美国-波兰关于肽模拟物设计的生物物理学研究

• 批准号: 9115796
• 负责人: Peter Kollman
• 金额: --
• 依托单位: University of California-San Francisco
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-01 至 1996-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9115796&HistoricalAwards=false
• 关键词: U.S.; Poland; Biophysics; Research; Design

The objective of this U.S.-Poland research project between Dr. Peter A. Kollman of the School of Pharmacy, University of California, San Francisco Center, and Dr. Piotr Cieplak of the University of Warsaw, Poland, is to carry out theoretical calculations to design peptide analogs that have the potential to be excellent inhibitors of the proteins HIV protease, thermolysin and elastase. The successful design of an inhibitor for this enzyme, should it prove of therapeutic value, could be used against the AIDS virus. The same type of design could be transferred to the inhibitor of other aspartyl proteases such as renin, which would provide therapy against hypertension. Selective inhibition of serine proteases such as human leucocyte elastase as a potential drug against emphysema or other such degenerative diseases might be achieved using the same principles. This project in biophysics fulfills the program objective of advancing scientific knowledge by enabling leading experts in the United States and Eastern Europe to combine complementary talents and pool resources in areas of strong mutual interest and competence.

加利福尼亚大学旧金山中心药学院的 Peter A. Kollman 博士和波兰华沙大学的 Piotr Cieplak 博士共同开展的这个美国-波兰研究项目的目的是进行理论计算，设计有潜力成为 HIV 蛋白酶、嗜热菌蛋白酶和弹性蛋白酶等蛋白质的优异抑制剂的肽类似物。 如果成功设计出这种酶的抑制剂，如果能证明其具有治疗价值，则可用于对抗艾滋病病毒。 相同类型的设计可以转移到其他天冬氨酰蛋白酶（例如肾素）的抑制剂，这将提供针对高血压的治疗。 使用相同的原理，可以选择性抑制丝氨酸蛋白酶，例如人白细胞弹性蛋白酶，作为对抗肺气肿或其他此类退行性疾病的潜在药物。 该生物物理学项目通过使美国和东欧的领先专家能够在共同感兴趣和能力强的领域结合互补人才并汇集资源，实现了推进科学知识的计划目标。