U.S.-Poland Biophysics Research on Design of Peptide Mimetics

点击翻译按钮获取中文摘要

The objective of this U.S.-Poland research project between Dr. Peter A. Kollman of the School of Pharmacy, University of California, San Francisco Center, and Dr. Piotr Cieplak of the University of Warsaw, Poland, is to carry out theoretical calculations to design peptide analogs that have the potential to be excellent inhibitors of the proteins HIV protease, thermolysin and elastase. The successful design of an inhibitor for this enzyme, should it prove of therapeutic value, could be used against the AIDS virus. The same type of design could be transferred to the inhibitor of other aspartyl proteases such as renin, which would provide therapy against hypertension. Selective inhibition of serine proteases such as human leucocyte elastase as a potential drug against emphysema or other such degenerative diseases might be achieved using the same principles. This project in biophysics fulfills the program objective of advancing scientific knowledge by enabling leading experts in the United States and Eastern Europe to combine complementary talents and pool resources in areas of strong mutual interest and competence.