U.S.-Brazil Cooperative Research: Origins of replication inthe DNA puffs of Rhynchosciara

该奖项由巴西计划和真核遗传学计划共同资助，支持弗吉尼亚大学医学院的乔伊斯·L·哈姆林博士和巴西圣保罗大学的弗朗西斯科·J·S·拉拉博士进行的生物学合作研究。研究的重点是了解复杂的真核基因组中的复制。该项目将研究对坐骨蝇Rhynchosciara americana唾液腺DNA泡沫区复制的控制。该系统提供了一个不同寻常的机会来检查在开发过程中对复制实施的特殊监管控制。这两个实验室之间的合作是协同的，从而允许在任何一个单独的小组中进行不可能进行的研究。Hamlin小组提供分子生物学方面的专业知识，而Lara小组则是Rhynchosciara生物学的所有方面的专家。

This award, co-funded by the Brazil Program and the Eukaryotic Genetics Program, supports cooperative research in biology to be conducted by Dr. Joyce L. Hamlin of the University of Virginia School of Medicine and Dr. Francisco J.S. Lara of the University of Sao Paulo, Brazil. The focus of the research is to gain an understanding of replication in complex eukaryotic genomes. The project will study the control of replication of the DNA puff regions in the salivary glands of the sciarid fly, Rhynchosciara americana. The system offers an unusual opportunity to examine special regulatory controls over replication that are exercised during development. The collaboration between the two laboratories is synergistic, thereby allowing studies that would be impossible to carry out in either of the individual groups. The Hamlin group offers expertise in molecular biology while the Lara group is expert in all aspects of the biology of Rhynchosciara.