Regulation of Vitamin D Metabolism - Mechanism of Parathyroid Hormone Action

维生素D帮助身体利用骨骼中的钙和磷， 神经和肌肉 然而，维生素D必须在 肾脏才能在体内发挥作用。 的因素之一 帮助肾脏激活维生素D是甲状旁腺激素。 这项拨款将研究甲状旁腺激素 刺激肾脏激活维生素D。 为了研究这个问题，我们 将使用大鼠，大鼠肾脏切片，以及从大鼠身上提取的细胞， 肾脏并在大鼠体外生长。 这些研究可能有助于治疗 糖尿病患者和老年人。 在这些 人，甲状旁腺激素可能不会刺激肾脏， 维生素D缺乏可能导致维生素D缺乏。 骨骼疾病。

Vitamin D helps the body use calcium and phosphorus in bones, nerves, and muscles. However, vitamin D must be activated in the kidney before it can work in the body. One of the factors which helps the kidney to activate vitamin D is parathyroid hormone. This grant will study the details of how parathyroid hormone stimulates the kidney to activate vitamin D. To study this, we will use rats, slices of rat kidney, and cells taken from the rat kidney and grown outside the rat. These studies may help to treat people who have diabetes and people who are elderly. In these people, parathyroid hormone may not stimulate the kidney to activate vitamin D, and lack of activated vitamin D may contribute to bone disease.