Inter- and Intramolecular Interactions of Luminescent Metal Complexes

发光金属配合物的分子间和分子内相互作用

• 批准号: 9118034
• 负责人: James Demas
• 金额: $ 23.31万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-12-15 至 1995-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9118034&HistoricalAwards=false
• 关键词: Inter; Intramolecular; Interactions; Luminescent; Metal

This award provides continued support from the Inorganic, Bioinorganic, and Organometallic Program for studies of the photophysics of d6 diimine complexes by Dr. James N. Demas, Chemistry Department, University of Virginia. The overall goal of the project is to develop rationally designed luminescent molecular probes for specific molecular sites. He will investigate the effect of the proximity of a long hydrophobic hydrocarbon chain on the emission properties of the d6 metal center. He will also study luminescent complexes intercalated into DNA with special emphasis on identification of fluorescence due to multiple bonding sites, and the rotational reorientation of the probe while bound to DNA. In the course of the study, Demas will assess the effectiveness of time resolved phase sensitive emission in characterizing environmental effects on excited state properties. Steady-state, pulsed, and phase fluorimetry, as well as NMR and crystallography, will be used to examine variations in state ordering and decay paths of luminescent Ru(II), Os(II), Ir(II), and Re(I) photosensitizers. %%% The electronic structure of luminescent metal complexes is sensitive to changes in local molecular environment. When such complexes are bound to species like DNA, their electronic characteristics may be modified by the location or the symmetry of the site. Conversely, complexes can be designed to detect the presence of certain sites. In this project, the sensitivity of a new technique to detect changes in the flouresence of the probe due to its molecular environment will be tested. In addition, the effect of changes in the hydrophobic environment on the luminescence of the metal complex will be investigated. The project has implications for sensor technology and for the design and application of new probes for the structure and dynamics of DNA and other chiral biopolymers.

该奖项提供了无机， 生物无机和有机金属研究计划 d6二亚胺配合物的电子物理学。底马， 弗吉尼亚大学化学系。 总目标 该项目的目的是开发设计合理的发光 用于特定分子位点的分子探针。 他将 研究长疏水性的邻近性的影响， 烃链对d6金属发射特性的影响 中心 他还将研究发光复合物插入 特别强调识别 荧光由于多个键合位点，和旋转 探针结合DNA时的重定向。 过程中 在这项研究中，德马斯将评估时间的有效性， 分辨相敏发射表征 环境对激发态性质的影响。 稳态、脉冲和相位荧光法，以及NMR和 晶体学，将用于检查状态的变化 发光Ru（II），Os（II），Ir（II）， 和Re（I）光敏剂。 %%% 发光金属配合物的电子结构是 对局部分子环境的变化敏感。 当这样 复合物与DNA等物质结合，它们的电子 特征可以通过位置或对称性来修改 的网站。 相反，复合物可以被设计成检测 某些网站的存在。 本工程 一种新技术的灵敏度，以检测变化， 探针由于其分子环境而产生的荧光 得到考验 此外，变化的影响 疏水环境对金属发光的影响 将进行调查。 该项目对以下方面有影响： 传感器技术和新的设计和应用 DNA和其他手性分子的结构和动力学探针 生物聚合物