Examining unconventional intramolecular interactions

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The objective of this project is to examine the physical basis of under-appreciated molecular interactions that occur within molecules, particularly those that may involve orbital mixing.Aims:-To examine whether heterocycles can accept electron density to form bonds with partial covalency (orbital mixing) from neighbouring electron-donor sites.-To examine the physicochemical nature of intramolecular hydrogen bonds.-To examine whether the unusual interactions identified in the above investigations can be exploited to tune chemical reactivity, or within catalysis.The above aims are being examined using a combination of synthetic and computational chemistry. Quantitative measurements will be made using NMR spectroscopy and compared with theoretical calculations via structure activity relationships.