Synthetic Analogs of Nickel Hydrogenases

镍氢化酶的合成类似物

• 批准号: 9118845
• 负责人: T. Daniel Stack
• 金额: $ 3.2万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1993-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9118845&HistoricalAwards=false
• 关键词: Synthetic; Analogs; Nickel; Hydrogenases

This research will explore the reactivity and structural chemistry of tervalent nickel in coordination environments which are thought to mimic those found for nickel hydrogenase enzymes. These enzymes are responsible for the reversible conversion of of hydrogen--an essential conversion in anaerobic metabolism for both chemotrophic and phototrophic bacteria. The coordination environment of the nickel site varies with different organisms. A consensus coordination sphere has 2-4 nitrogen or oxygen donors and 1-3 sulphur or selenium donors around nickel. Stabilization of nickel in its tervalent oxidation state will be a significant synthetic challenge due to the propensity of these systems to degrade by disulfide formation and concomitant metal reduction. A new class of ligands based on triazacyclononane will be designed and synthesized to circumvent this problem. The incorporation of other metals in this unique coordination environment will also be investigated. %%% This award is made as the starter grant increment of Dr. Daniel Stack's Postdoctoral Research Fellowship in Chemistry in support of his research at Stanford University. The thrust of Dr. Stack's research is the design, synthesis and characterization of analogs of nickel hydrogenases.

本研究将探讨反应性和结构 配位环境中的三价镍化学 这被认为是模仿那些发现镍氢化酶 内切酶 这些酶负责可逆的 氢的转化--厌氧反应中的一个重要转化 化学营养型和光养型细菌的代谢。的 镍位点的配位环境随 不同的生物体。共识协调领域有2-4个 氮或氧供体和1-3个硫或硒供体 围绕镍。三价镍的稳定化 氧化态将是一个重大的合成挑战， 这些系统的二硫化物降解倾向 形成和伴随的金属还原。一类新的 将设计基于三氮杂环壬烷的配体， 合成来解决这个问题。掺入 在这种独特的配位环境中的其他金属也将 追究 %%% 这个奖项是作为博士的启动补助金增量。丹尼尔 斯塔克的博士后研究奖学金在化学 支持他在斯坦福大学的研究。的推力 斯塔克博士的研究是设计，合成和 镍氢化酶类似物的表征。