Pathogenesis of Device-Related Infections

细菌感染通常伴随着生物医学植入物， 留置导管 这些感染对 治疗，他们坚持和复发，直到删除的 假体材料 这个跨学科项目的目的是 是了解与植入器械相关的病理生理学 感染，并开发适合减少 细菌粘附并且对感染有抵抗力。 细胞结合 蛋白质研究将确定预吸附蛋白质的作用， 单克隆抗体和受体缺陷型突变体 感染因子对葡萄球菌粘附和中性粒细胞 activation. 具有不同物理化学性质的新型聚合物 属性将被合成，以检查这些属性如何 性质影响葡萄球菌和中性粒细胞粘附。 这些研究应该有助于材料的开发， 抗感染，使植入物使用更安全 用于许多外科应用的器械。

Bacterial infections often accompany biomedical implants and indwelling catheters. These infections are resistant to treatment and they persist and recur until removal of the prosthetic material. The aim of this cross-disciplinary project is to understand the pathophysiology of implant-device related infection, and to develop materials that are tailored to reduce bacterial adhesion and are resistant to infections. Cell-binding protein studies will determine the role of preadsorbed proteins, monoclonal antibodies and receptor-deficient mutants of the infectious agent on staphylococcal adhesion and neutrophil activation. Novel polymers with different physicochemical properties will be synthesized in order to examine how these properties influence staphylococcal and neutrophil adhesion. These studies should aid the development of materials that are resistant to infection, leading to the safer use of implant devices for many surgical applications.