Pathogenesis of Device-Related Infections

设备相关感染的发病机制

• 批准号: 9120660
• 负责人: Stuart Cooper
• 金额: $ 32.93万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-01 至 1993-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9120660&HistoricalAwards=false
• 关键词: Pathogenesis; Device; Related; Infections

Bacterial infections often accompany biomedical implants and indwelling catheters. These infections are resistant to treatment and they persist and recur until removal of the prosthetic material. The aim of this cross-disciplinary project is to understand the pathophysiology of implant-device related infection, and to develop materials that are tailored to reduce bacterial adhesion and are resistant to infections. Cell-binding protein studies will determine the role of preadsorbed proteins, monoclonal antibodies and receptor-deficient mutants of the infectious agent on staphylococcal adhesion and neutrophil activation. Novel polymers with different physicochemical properties will be synthesized in order to examine how these properties influence staphylococcal and neutrophil adhesion. These studies should aid the development of materials that are resistant to infection, leading to the safer use of implant devices for many surgical applications.

细菌感染通常伴随着生物医学植入物和留置导管。这些感染对治疗有抵抗力，它们会持续并复发，直到移除假体材料。这一跨学科项目的目的是了解植入物相关感染的病理生理学，并开发可减少细菌黏附并具有抗感染能力的材料。细胞结合蛋白研究将确定感染因子的预吸附蛋白、单抗和受体缺陷突变体在葡萄球菌黏附和中性粒细胞激活中的作用。将合成具有不同物理化学性质的新型聚合物，以检验这些性质如何影响葡萄球菌和中性粒细胞的黏附。这些研究应该有助于开发抗感染的材料，从而使植入设备在许多外科应用中得到更安全的使用。