Developing Cryosuit - usability and performance validation of our portable, rapid cooling device for heat-related illness.

** 开发Cryosuit -我们的便携式快速冷却设备的可用性和性能验证，用于与热有关的疾病。**高温引起的疾病和并发症对全球人口健康和经济产生重大影响。中暑会导致重要器官损伤，如果不迅速进行降低核心体温的治疗，会导致严重虚弱或死亡。2000-2009年期间，中暑等热相关疾病（HRI）在英国造成38.5亿英镑的损失[CCC.org-2019\]。到2030年，热应激将使全球经济每年损失1.8万亿英镑的生产力和医疗保健[联合国，2019]。因此，全球变暖和极端天气模式的日益规律性推动了对治疗HRI的新技术的迫切需求，2018年环境审计委员会的一份报告预测，“到2050年，与高温有关的死亡人数将增加两倍”。CryoGenx旨在通过Cryosuit从根本上颠覆价值3.6亿英镑的“冷疗法”热病治疗市场;我们的便携式快速冷却设备用于现场治疗HRI。紧凑、自供电、重量轻，易于操作，可在任何情况下有效部署，克服了当前冷却方法的物流障碍和资源依赖性。关键是，Cryosuit将使救生冷却能够尽快启动;影响患者预后的最大因素。基于我们最初的Cryosuit原型-初步测试的数据显示，与现有的现场HRI处理方法相比，该方法具有2.5倍的冷却速度，3倍的持续时间和70%的成本降低-该实验开发项目将优化该技术以证明其可用性，在伯明翰大学医院NHS基金会信托基金的支持下，我们将通过以人为本的设计原则将我们的技术开发成全尺寸的V2原型，并在布鲁内尔大学，空中救护车，Balfour Beatty和英国特种部队。该项目的产出将是：* 符合人体工程学设计的TRL 6原型和包装与集成气体输送系统 * 临床数据集和验证，从最终用户现场试验

**Developing the Cryosuit - usability and performance validation of our portable, rapid cooling device for heat-related illness.**Illness and complications brought on by heat has a significant impact on population health and economies worldwide. Heatstroke causes vital organ damage, leading to serious debilitation or death, if treatment to lower core body temperature is not administered quickly.Heat-related illnesses(HRI) such as heat stroke cost the UK £3.85bn between 2000-2009 \[CCC.org-2019\]. By 2030, heat stress will cost the global economy £1.8 trillion/year in lost productivity and healthcare\[UN,2019\].Global warming and the increasing regularity of extreme weather patterns is therefore driving an urgent need for new technologies to treat HRI, with a 2018 Environmental Audit Committee report predicting "heat-related deaths are set to treble by 2050" in the UK without Government intervention.Cryogenx aims to radically disrupt the £360m 'cold therapy' heat illness treatment market with Cryosuit; our portable rapid cooling device for treating HRI in-the-field. Compact, self-powered and lightweight, it's easy to operate and can be effectively deployed in any scenario, overcoming the logistical barriers and resource dependency of current cooling methods.Critically, Cryosuit will enable life-saving cooling to be initiated as rapidly as possible; the single largest factor influencing patient outcome.Building on our initial Cryosuit prototype - which data from preliminary tests shows to have 2.5x faster cooling rate, 3x duration, and 70% reduction in cost compared to existing field HRI treatment methods - this experimental development project will optimise the technology to demonstrate the usability, safety and efficacy required to be a recognised healthcare solution.With support form University Hospitals Birmingham NHS Foundation Trust, we'll develop our technology via human-centred-design principles into a full-scale V2 prototype, validated in field-trials with Brunel University, Air Ambulance, Balfour Beatty and UK Special Forces.The projects outputs will be:* Ergonomically designed TRL6 prototype and packaging with integrated gas delivery system* Clinical datasets and validation from end-user field trials