Subcellular Targeting of a Presynaptic Nerve Terminal Protein, SNAP-25

突触前神经末梢蛋白 SNAP-25 的亚细胞靶向

• 批准号: 9121121
• 负责人: Michael Wilson
• 金额: $ 27.76万
• 依托单位: The Scripps Research Institute
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 1995-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9121121&HistoricalAwards=false
• 关键词: Subcellular; Targeting; Presynaptic; Nerve; Terminal

The function of the brain, memory and learning and behavior is critically dependent on nerve cells to transmit, process and store information. To fulfill these tasks neurons possess unique structures - extensions of their cell body (dendrites and axons)- that terminate (synapse) on other cells to allow electrical and chemical communication between them. These synaptic junctions are the localized sites where neurotransmitters are stored, released, synthesized and recycled. The characterization of the molecular and chemical components of the synapse such as the protein SNAP-25, is an important goal of research in the understanding of the nervous system. SNAP-25 is a prominent protein found in nerve terminals of the mature nervous system only and seems to be preserved up through the animal kingdom suggesting that it has important nervous system function.

大脑的功能，记忆，学习和行为， 严重依赖于神经细胞来传递、处理和储存 信息. 为了完成这些任务，神经元具有独特的 结构-细胞体的延伸（树突和轴突）- 在其他细胞上终止（突触）， 它们之间的化学联系。 这些突触连接 神经递质储存，释放， 合成并回收。 分子表征 以及突触的化学成分，如蛋白质SNAP-25， 是研究的一个重要目标， 神经系统 SNAP-25是在神经细胞中发现的一种重要蛋白质， 只有成熟神经系统的末端， 在整个动物王国中保存下来， 重要的神经系统功能。