Interrogating protein hydration by terahertz time-domain spectroscopy

用太赫兹时域光谱学研究蛋白质水合作用。该项目旨在开发先进的太赫兹时域光谱(THz-TDS)技术，以了解蛋白质与溶液中辅料的相互作用如何改变其周围的水化层，以及这如何影响粘度和稳定性等性质。THz-TDS可以检测到蛋白质周围重叠的延长水化层，揭示了蛋白质-蛋白质相互作用和蛋白质在水环境中的行为的新知识。计划的结果是使用THz-TDS来更好地了解蛋白质(如单抗)在高浓度溶液中是如何相互作用的，并在这样做的过程中制造更好的药物。

Interrogating protein hydration by terahertz time-domain spectroscopy. This project aims to develop advanced terahertz time-domain spectroscopy (THz-TDS) techniques to understand how a protein’s interaction with excipients in solution can alter the hydration layers around them and how this affects properties such as viscosity and stability. THz-TDS can detect overlapping extended hydration layers around proteins, revealing new knowledge in protein-protein interactions and protein behaviour in an aqueous environment. The intended outcome is to use THz-TDS to better understand how proteins such as monoclonal antibodies interact in high concentration solutions, and in doing so make better medicines.