Intestinal Microbial Composition Potentiates Citrobacter rodentium-Induced Autoimmunity and Parkinson's Disease-like Symptoms in Pink1-/- Mice

肠道微生物成分增强 Pink1-/- 小鼠柠檬酸杆菌诱导的自身免疫和帕金森病样症状

• 批准号: 416922
• 负责人: Cannon Tyler
• 金额: $ 7.65万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-11-01 至 2022-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=416922&lang=en
• 关键词: Autoimmune; Colitis; Infection; Intestinal; Microbiota; Neurodegeneration; Parkinson'S Disease

Over the years, it has become increasingly clear that the gut and the brain are intertwined in their physiology - a concept that has since been coined the gut-brain axis. The collection of microbes living within the gut, which itself can alter gut functio

多年来，越来越清楚的是，肠道和大脑在生理上是交织在一起的——这个概念后来被创造为肠脑轴。肠道菌群生活在肠道内的微生物群，它们本身可以改变肠道功能