Investigating the mechanism of constitutive activation of PKG Ib R177Q in thoracic aortic disease

探讨胸主动脉疾病中 PKG Ib R177Q 组成型激活的机制

• 批准号: 428682
• 负责人: Ahmed Alveena
• 金额: $ 1.27万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-12-01 至 2020-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=428682&lang=en
• 关键词: Acute Aortic Dissections; Allostery; Biomolecular Nmr; Cgmp; Cgmp-Dependent Protein Kinase; Cyclic Nucleotide Signalling; Drug Design; Protein Dynamics; Structural Determination; Thoracic Aortic Aneurysms

"Protein Kinase G (PKG) is a major regulator of smooth muscle tone and its malfunction can cause cardiac disorders. Specifically, a genetic mutation (R177Q) in its cyclic nucleotide binding domain A (CBD-A) renders PKG I constitutively active, resulting i

“蛋白激酶G（PKG）是平滑肌张力的主要调节剂，其功能障碍可导致心脏疾病。具体而言，其环核苷酸结合结构域A（CBD-A）中的基因突变（R177 Q）使PKG I具有组成性活性，导致PKG I的活性降低。