Self-assembled supramolecular cages for guest binding and catalysis

用于客体结合和催化的自组装超分子笼

• 批准号: DP230100190
• 负责人: Dr Nicholas White
• 金额: $ 26.67万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100190
• 关键词: Self; assembled; supramolecular; cages; guest

This project aims to construct a family of supramolecular metal-containing cage-shaped molecules that possess specialised binding pockets with unique chemical properties that mimic enzymes. Many existing cage molecules contain well-defined three dimensional cavities reminiscent of enzymes' active sites. However, unlike natural systems they do not contain "active" metals with free coordination sites, and this limits their catalytic ability. This project aims to prepare a large family of robust organic cages quickly and easily, and subsequently incorporate metals containing free active sites that point into the cage cavity. It is expected that this will deliver strong and selective guest binding, and efficient and selective catalysis.

该项目旨在构建一个具有特殊结合口袋的超分子金属笼子形分子，具有模仿酶的独特化学特性。许多现有的笼子分子包含定义明确的三维腔，让人联想到酶的活性位点。但是，与天然系统不同，它们不包含具有自由协调位点的“活跃”金属，这限制了它们的催化能力。该项目旨在快速，轻松地准备大型健壮的有机笼子，然后融合包含指向笼子腔的免费活跃位点的金属。预计这将提供强大而有选择性的访客结合，并有效，有选择性的催化。