Improvements in Aerobic Bioreactor Cell Capacity through FacFacilitated Oxygen Transport Agents

Aquanautics公司合成并表征氧结合络合物。这些化合物旨在用于商业应用，从除氧(例如，饮料氧气过滤器)到低功率氧气生产(例如，“人造鳃”)。该项目旨在开发这些化合物中的一部分，以促进氧气流向酿酒酵母(面包酵母)和哺乳动物细胞。这项提议的目标有两个。其一是证明原生动物和后生动物培养物与过渡金属结合化合物是相容的。另一种是证明这种添加剂能够维持更高的细胞密度或更高的细胞代谢率。如果这项研究成功，就可以更经济地生产细胞基因产品。

Aquanautics Corporation synthesizes and characterizes oxygen binding complexes. These compounds are intended for commercial applications ranging from oxygen removal (for example, beverage oxygen filters) to low power oxygen production (for example, the "artificial gill"). This project is to exploit some of these compounds as agents to facilitate oxygen flux to Saccharomyces cerevisae (Baker's yeast) and mammalian cells. The objective of this proposal is twofold. One is to show that protozoan and metazoan cultures are compatible with transition metal binding compounds. The other is to demonstrate that such an additive will enable the maintenance of higher cell densities or higher cell metabolism rates. If this research is successful, the cell genetic products can be produced more economically.