Improvements in Aerobic Bioreactor Cell Capacity through FacFacilitated Oxygen Transport Agents

通过 Fac 促进氧运输剂提高需氧生物反应器细胞容量

• 批准号: 9161004
• 负责人: John Kerr
• 金额: $ 5万
• 依托单位: Aquanautics Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-01-01 至 1992-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9161004&HistoricalAwards=false
• 关键词: Improvements; Aerobic; Bioreactor; Cell; Capacity

Aquanautics Corporation synthesizes and characterizes oxygen binding complexes. These compounds are intended for commercial applications ranging from oxygen removal (for example, beverage oxygen filters) to low power oxygen production (for example, the "artificial gill"). This project is to exploit some of these compounds as agents to facilitate oxygen flux to Saccharomyces cerevisae (Baker's yeast) and mammalian cells. The objective of this proposal is twofold. One is to show that protozoan and metazoan cultures are compatible with transition metal binding compounds. The other is to demonstrate that such an additive will enable the maintenance of higher cell densities or higher cell metabolism rates. If this research is successful, the cell genetic products can be produced more economically.

Aquanautics公司合成并表征氧结合配合物。这些化合物旨在用于商业应用，从除氧（例如，饮料氧气过滤器）到低功率氧气生产（例如，“人工鳃”）。这个项目是利用这些化合物中的一些作为促进氧气流向酿酒酵母（贝克酵母）和哺乳动物细胞的试剂。这项建议的目的是双重的。一是证明原生动物和后生动物培养物与过渡金属结合化合物是相容的。另一个是证明这种添加剂能够维持较高的细胞密度或较高的细胞代谢率。如果这项研究取得成功，细胞遗传产品的生产将更加经济。