Enhanced wave bioreactor design for highly aerobic fermentation processes

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Bioreactors are devices used in bioprocesses to produce a variety of valuable biological products such as pharmaceuticals, food ingredients, biodegradable plastic materials and clean transportation fuels. There are many types of bioreactors. A few years ago, a new type of bioreactor design was introduced for the production of therapeutics derived from animal-cell cultures. The required aeration for these cultures is obtained by creating waves at the surfaces of the culture by a rocking motion of it placed in a plastic bag. These so-called “wave bioreactors” are cost-effective compared to the traditional ones based on mechanically-stirred steel-tank devices for those applications. However their applications are limited to cases for low levels of aeration-mixing. One of the objectives of this research is to modify the generic wave bioreactor design to allow its use in microbial fermentation processes which require higher aeration-mixing capabilities.