Chiroptical Properties of Chiral Acyclic Dienes: Studies in Atropisomerism

手性无环二烯的手性光学性质：阻转异构现象的研究

• 批准号: 9200868
• 负责人: Harry Walborsky
• 金额: $ 25.61万
• 依托单位: Florida State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-05-01 至 1996-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9200868&HistoricalAwards=false
• 关键词: Chiroptical; Properties; Chiral; Acyclic; Dienes

This grant from the Organic Dynamics Program supports the work of Professor Harry M. Walborsky at Florida State University. The chiroptical properties of acyclic 1,3-dienes will be studied. A general method for the preparation of chiral atropisomers of acyclic 1,3-dienes will be devised which utilizes as a key step a cyclopropyl carbinyl rearrangement. The relative and absolute configurations of the chiral 1,3-dienes as well as their chiral precursors will be determined and correlations with various sector rules will be attempted. The rates and activation energies for the thermal racemizations of the dienes will also be established. %%% Compounds which exist as nonsuperimposable mirror images by virtue of hindered rotation about a single bond between two carbon atoms will be examined. A new method for constructing these molecules will be developed. The three dimensional arrangement of the atoms will be determined and the rate at which the two mirror images interconvert will be determined.

这项来自有机动力学项目的资助支持了这项工作 哈利·M教授沃尔博斯基在佛罗里达州立大学。 无环1，3-二烯的手性性质将是 研究了 制备手性化合物的一般方法 将设计非环状1，3-二烯的阻转异构体， 利用环丙基原基重排作为关键步骤。 手性化合物的相对构型和绝对构型 1，3-二烯以及它们的手性前体将是 将确定与各种行业规则的相关性， 企图。 热分解的速率和活化能 还将建立二烯的外消旋化。 %%% 以不可重叠的镜像存在的化合物， 由于两个分子之间的单键旋转受阻， 将检查碳原子。 一种新的构造方法 这些分子将被开发出来。 三维 原子的排列将被确定， 将确定两个镜像图像相互转换。