Non-Canonical Amino Acids for Protein Analysis and Peptide Inhibitors

用于蛋白质分析和肽抑制剂的非规范氨基酸

• 批准号: DP230100079
• 负责人: Prof Thomas Huber
• 金额: $ 52.17万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-03-27 至 2026-03-26
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100079
• 关键词: Non; Canonical; Amino; Acids; Protein

This interdisciplinary project aims to establish new tools to experimentally confirm 3D structure predictions of proteins that are otherwise difficult to study. A combination of innovative biochemistry, modern spectroscopy, and high-performance computing will be applied to study protein-protein and protein-ligand interactions. The project expects to generate new techniques and to test them on established drug targets. Expected outcomes include new tools which quickly inform medicinal chemists how drugs interact with their targets and how they can be improved. The developed tools should provide significant benefit to many researchers by accelerating the early stage of drug discovery, and support Australia’s fast growing biotechnology sector.

这个跨学科项目旨在建立新的工具，以实验方式确认蛋白质的3D结构预测，否则很难研究。创新的生物化学，现代光谱学和高性能计算的组合将被应用于研究蛋白质-蛋白质和蛋白质-配体相互作用。该项目预计将产生新的技术，并在既定的药物靶点上进行测试。预期成果包括新的工具，快速告知药物化学家药物如何与其目标相互作用，以及如何改善它们。开发的工具应该通过加速药物发现的早期阶段为许多研究人员提供显着的好处，并支持澳大利亚快速增长的生物技术部门。