Three-dimensional structure determination of biomolecular assemblies from sparse data of different length scales

从不同长度尺度的稀疏数据确定生物分子组装体的三维结构

• 批准号: DP120100561
• 负责人: Prof Thomas Huber
• 金额: $ 43.74万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP120100561
• 关键词: Three; dimensional; structure; determination; biomolecular

New computer algorithms will be combined with sparse experimental structure restraints, obtained with novel protein chemistry technologies, to generate accurate three-dimensional (3D) models of proteins and protein assemblies in solution and in the solid state. The new strategies will greatly increase the number of protein targets amenable to rational drug design.

新的计算机算法将结合稀疏的实验结构的限制，获得新的蛋白质化学技术，以产生精确的三维（3D）模型的蛋白质和蛋白质组装在溶液中，并在固态。新的策略将大大增加蛋白质靶点的数量，以适应合理的药物设计。