PRF: Origin and Maintenance of Pericentric-inversion Polymorphism in the Deer Mouse, Peromyscus maniculatus

本研究的主要目的是评估 区域内限制性位点和DNA序列变异 常见于常见的6号染色体臂间倒位 鹿鼠（Peromyscus maniculatus），并确定是否 特定DNA单倍型之间存在连锁不平衡， 这条染色体的三种变体 这些数据将 用于评估两个备选假设的起源 （单系或趋同）和维护（选择或 复发性突变）的广泛中心周围倒位 东北马鹿及其近缘种鹿鼠的多态性 Sitkensis和P.oreas。 样本将包括鹿鼠 收集自北美各地的自然种群。 的 Maniculatus的围心反转系统代表了一个 理想的哺乳动物模型，以测试的一般适用性 遗传假说和进化原理来自于 果蝇近着丝粒倒位系统 伪暗

The primary objectives of this research are to assess restriction-site and DNA-sequence variation within the region common to pericentric inversions of chromosome 6 in the common deer mouse (Peromyscus maniculatus), and to determine whether linkage disequilibrium exists between specific DNA haplotypes and each of the three morphs of this chromosome. These data will be used to evaluate two alternative hypotheses for the origin (monophyletic or convergent) and maintenance (selection or recurrent mutation) of the widespread pericentric-inversion polymorhisms in P. maniculatus and the related deer mouse species P. sitkensis and P. oreas. The sample will include deer mice collected from natural populations throughout North America. The pericentric-inversion system of P. maniculatus represents an ideal mammalian model to test the general applicability of the genetic hypotheses and evolutionary principles derived from the paracentric-inversion system of the fruit fly Drosphila pseudoobscura.