PRF: Origin and Maintenance of Pericentric-inversion Polymorphism in the Deer Mouse, Peromyscus maniculatus

PRF：鹿鼠 Peromyscus maniculatus 中心周倒位多态性的起源和维持

• 批准号: 9201509
• 负责人: David Hale
• 金额: $ 6.96万
• 依托单位: Individual Award
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-01 至 1995-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9201509&HistoricalAwards=false
• 关键词: PRF; Origin; Maintenance; Pericentric; inversion

The primary objectives of this research are to assess restriction-site and DNA-sequence variation within the region common to pericentric inversions of chromosome 6 in the common deer mouse (Peromyscus maniculatus), and to determine whether linkage disequilibrium exists between specific DNA haplotypes and each of the three morphs of this chromosome. These data will be used to evaluate two alternative hypotheses for the origin (monophyletic or convergent) and maintenance (selection or recurrent mutation) of the widespread pericentric-inversion polymorhisms in P. maniculatus and the related deer mouse species P. sitkensis and P. oreas. The sample will include deer mice collected from natural populations throughout North America. The pericentric-inversion system of P. maniculatus represents an ideal mammalian model to test the general applicability of the genetic hypotheses and evolutionary principles derived from the paracentric-inversion system of the fruit fly Drosphila pseudoobscura.

本研究的主要目的是评估普通鹿小鼠6号染色体着丝粒周围倒位共同区域内的限制性内切酶和DNA序列变异，并确定特定的DNA单倍型与该染色体的三种形态之间是否存在连锁不平衡。这些数据将被用来评估两种可供选择的假说，即广泛存在的马尾鹿及其近缘鹿鼠种西克鹿和美洲鹿的中心着丝粒倒位多态的起源(单系或收敛)和维持(选择或重复突变)。样本将包括从北美各地自然种群中收集的鹿鼠。黑腹果蝇着丝粒倒位系统是检验果蝇近着丝点倒位系统遗传假说和进化原理的普遍适用性的理想哺乳动物模型。