Mechanisms of niche – stem cell unit origin and maintenance (A11)

â干细胞单位起源和维持的机制生态位（A11）

• 批准号: 260442193
• 金额: --
• 依托单位: Centre for Organismal Studies (COS)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/260442193?language=en
• 关键词: Mechanisms; niche; stem; cell; unit

The stem cell niche is key to maintain stemness in every stem cell population reported in plants and animals. Despite the essential function of stem cell - niche interaction in stem cell biology, little is known about how somatic stem cells and niche get together during organ formation. In the previous funding period, we used neuromasts, sensory organs of the lateral line system in fish, as a minimal model to explore niche-stem cell interaction during organogenesis. We will now exploit this system to address niche formation at the molecular level by combining our expertise in 4D imaging and lineage analysis with the acquisition of new RNAseq data, to identify molecular determinants critical for niche induction and maintenance during homeostasis and perturbed conditions.

干细胞生态位是维持植物和动物中报道的每一个干细胞群体的干细胞性的关键。尽管干细胞-小生境相互作用在干细胞生物学中起着重要作用，但对体干细胞和小生境在器官形成过程中如何聚集却知之甚少。在上一个资助期间，我们使用神经乳突，在鱼的侧线系统的感觉器官，作为一个最小的模型，探索在器官发生过程中的小生境干细胞的相互作用。我们现在将利用这个系统，通过将我们在4D成像和谱系分析方面的专业知识与新RNAseq数据的获取相结合，在分子水平上解决生态位形成问题，以确定在稳态和扰动条件下对生态位诱导和维持至关重要的分子决定因素。