Long and Medium-Term Research: Isolation and Characterization of Inhibitors of FOS/JUN DNA-Binding Function

长期和中期研究：FOS/JUN DNA 结合功能抑制剂的分离和表征

• 批准号: 9203286
• 负责人: Carlos Molina
• 金额: $ 4.2万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-15 至 1994-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9203286&HistoricalAwards=false
• 关键词: Long; Medium; Term; Research; Isolation

Long & Medium-Term Research: Isolation and Characterization of Inhibitors of FOS/JUN DNA-Binding Function This award is under the Long and Medium-Term Research at Foreign Centers of Excellence Program, which enables U.S. scientists and engineers to conduct three to twelve months of research abroad at research centers of proven excellence. The program's awards provide opportunities for joint research, and the use of unique or complementary facilities, expertise and experimental conditions abroad. This award will support a twelve-month postdoctoral research visit by Dr. Carlos Molina-Nazario to work with Dr. Paolo Sassone- Corsi at the Laboratoire de Genetique Molecularie des Eucaryotes, CNRS in Strasbourg, France. The purpose of this research project is to find suppressor(s) of the Fos/Jun transactivating activity. Fos and Jun are transcriptional activators that belong to the early response gene class. They mediate the translation of extracellular signals into long term cellular response such as cell growth and differentiation. They are also defined proto-oncogenes because they can act as transforming genes if activated. The transforming activity seems to be related to the transactivating properties. Therefore factors involved in the suppression of the Fos-Jun transactivating properties are likely to be involved in the control of the cell proliferation and transformation. The purpose of the project can be summarized as follows: to isolate and characterize the factor IP-1 (a specific repressor of Fos/Jun function) and study its involvement in the control of Fos/Jun transactivating properties, and to characterize IP-1's role in cell proliferation and transformation. The learning of these unique methods in molecular biology and the general systems of molecular carcinogenesis will help Dr. Molina-Nazario for the future study of the molecular mechanism involved in the onset of cancer. The award recommendation provides funds to cover a stipend for twelve months, a dependent allowance and return airfare.

长期中期研究：分离和表征 FOS/JUN DNA结合功能抑制剂 该奖项是根据长期和中期研究， 外国卓越中心计划，使美国 科学家和工程师将进行三到十二个月的 在国外被证明卓越的研究中心进行研究。 的 该计划的奖项提供了联合研究的机会， 利用独特或互补的设施、专门知识和 国外的实验条件。 该奖项将支持为期十二个月的博士后研究访问 由卡洛斯莫利纳-纳扎里奥博士与保罗·萨松内博士合作- Corsi在真核生物分子遗传学实验室， 法国斯特拉斯堡的CNRS。 本研究项目的目的是寻找抑制剂（S）的 Fos/Jun反式激活活性。 Fos和Jun是转录的 属于早期反应基因类的激活剂。 他们 介导细胞外信号的翻译， 细胞反应，如细胞生长和分化。 他们是 也定义了原癌基因，因为它们可以作为转化 基因如果被激活 转化活动似乎与 反式激活特性 因此， Fos-Jun反式激活特性的抑制可能 参与细胞增殖的控制， 转型 该项目的目的可以概括为 如下：分离和表征因子IP-1（一种特异性 Fos/Jun功能的阻遏物），并研究其参与 控制Fos/Jun反式激活特性，并表征 IP-1在细胞增殖和转化中的作用。 的学习 这些独特的分子生物学方法和一般系统 分子致癌作用将有助于Molina-Nazario博士 未来研究的分子机制参与发病的 癌 奖励建议提供资金，以支付津贴， 12个月、受扶养人津贴和回程机票。