Juvenile Hormone-Specific Epoxide Hydrolyase: Regulation and Characterization
保幼激素特异性环氧化物水解酶:调节和表征
基本信息
- 批准号:9205637
- 负责人:
- 金额:$ 34.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:1992
- 资助国家:美国
- 起止时间:1992-08-15 至 1997-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Dr. Schooley will study an enzyme, called JH-specific epoxide hydrolase (JHEH), thought to be important in regulating juvenile hormone (JH) levels in insects. JH levels in insects are believed to be controlled partly by the rate of hormone degradation. A dogma has developed that the drop in JH level required for pupation of insects including moths and butterflies is due mainly to the JH- specific esterase. He has preliminary evidence that JHEH is at least as important as the esterase enzyme, if not more so. He will characterize the enzyme in live insects and in insect extracts to gain an understanding of its importance in controlling JH level. He will do this by studying JH metabolism as a function of development and by studying the rate of metabolism of different kinds of JH. He will determine portions of the protein sequence of the pure, isolated enzyme, and then isolate a molecular clone of the gene encoding the enzyme in order to determine the complete sequence of the enzyme. He will also test how enzyme levels are controlled by studying the levels of messenger RNA coding for the enzyme.
Schooley博士将研究一种酶,称为JH特异性环氧化物 水解酶(JHEH),被认为在调节青少年 激素(JH)在昆虫中的水平。据信昆虫体内的JH水平 部分受激素降解速率的控制。教条 已经发现,JH水平下降所需的化蛹, 包括飞蛾和蝴蝶在内的昆虫主要是由于JH- 特异性酯酶他有初步证据表明JHEH在 至少和酯酶一样重要,如果不是更重要的话。他将 表征活昆虫和昆虫提取物中的酶, 了解其在控制JH水平中的重要性。 他将通过研究JH代谢作为以下函数来做到这一点 发展和研究不同的代谢率 JH的种类他将确定部分的蛋白质序列, 分离纯化酶,然后分离 基因编码的酶,以确定完整的 酶的序列。他还将测试酶水平如何 通过研究信使RNA的水平来控制, 酵素
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David Schooley其他文献
David Schooley的其他文献
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{{ truncateString('David Schooley', 18)}}的其他基金
Characterization of Antidiuretic Factors
抗利尿因子的表征
- 批准号:
9602148 - 财政年份:1996
- 资助金额:
$ 34.5万 - 项目类别:
Continuing Grant
Acquisition of Equipment for Studies of Protein Structure and Function at the University of Nevada, Reno
购买内华达大学里诺分校蛋白质结构和功能研究设备
- 批准号:
9512482 - 财政年份:1995
- 资助金额:
$ 34.5万 - 项目类别:
Standard Grant
Acquisition of a Quadrupole Mass Spectrometer for the University of Nevado-Reno
为内华达雷诺大学购置四极杆质谱仪
- 批准号:
9102839 - 财政年份:1991
- 资助金额:
$ 34.5万 - 项目类别:
Standard Grant
Metabolism of Isoleucine to Insect Juvenile Hormone II via Propionyl-Coenzyme A
异亮氨酸通过丙酰辅酶 A 代谢为昆虫保幼激素 II
- 批准号:
8919257 - 财政年份:1990
- 资助金额:
$ 34.5万 - 项目类别:
Continuing Grant
Biosynthesis of the Juvenile Hormones: Studies on the Early Steps in the Genesis of the Carbon Skeletons
保幼激素的生物合成:碳骨架起源早期步骤的研究
- 批准号:
8518299 - 财政年份:1986
- 资助金额:
$ 34.5万 - 项目类别:
Continuing Grant
Titers of Known Juvenile Hormones in Various Insect Species,And Investigation of Suspected Unique Jh's in Oncopeltus And Attacus
不同昆虫种类中已知保幼激素的滴度以及Oncopeltus和Attacus中可疑的独特Jh的调查
- 批准号:
8208665 - 财政年份:1982
- 资助金额:
$ 34.5万 - 项目类别:
Continuing Grant
Insect Juvenile Hormones - Physiological Titers, Biosynthesis and Regulation, and a Search For a New Hormone
昆虫保幼激素 - 生理滴度、生物合成和调节以及新激素的探索
- 批准号:
8012027 - 财政年份:1980
- 资助金额:
$ 34.5万 - 项目类别:
Continuing Grant
Insect Juvenile Hormones - Their Biosynthesis and Physiological Titers During Development
昆虫保幼激素 - 发育过程中的生物合成和生理滴度
- 批准号:
7815397 - 财政年份:1978
- 资助金额:
$ 34.5万 - 项目类别:
Continuing Grant
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