Purchase of a Differential Titration Calorimeter

化学研究仪器计划授予北伊利诺伊大学化学系的这一奖项将有助于获得差示滴定量热仪。此次收购将加强化学研究，涉及生物膜系统的蛋白质稳定性和反应性以及配体结合特性的热力学研究，即(A)细胞色素c和细胞色素c过氧化物酶之间的络合物形成，(B)血红素(III)血红素蛋白中的结构/功能关系，(C)镁对细菌视紫红质构象的影响和(D)生物膜与非极性和两亲性分子相互作用的热力学研究。量热法已被广泛用于研究物理转变和研究均相和非均相化学反应的动力学。分析反应的热变化有助于研究催化剂表面、聚合物、胶束的形成以及蛋白质的某些配体结合反应。

This award from the Chemistry Research Instrumentation Program to the Department of Chemistry at Northern Illinois University will help acquire a Differential Titration Calorimeter. The acquisition will enhance chemical research involving thermodynamic studies of protein stability and reactivity and ligand binding properties of biological membrane systems, i.e., (a) complex formation between cytochrome c and cytochrome c peroxidase, (b) structure/function relationships in heme(III) heme proteins, (c) the influence of Mg2+ on the conformation of bacteriorhodopsin and (d) thermodynamics studies of the interactions between biological membranes and nonpolar and amphipathic molecules. Calorimetry has been extensively used for the study of physical transformations and for the investigation of the kinetics of both homogeneous and heterogeneous chemical reactions. Analysis of the heat changes of reactions is useful in studying catalyst surfaces, polymers, micelle formation, and certain ligand binding reactions of protein.