Grant for Exploratory Research: Novel Methods for AttachingDNA to a Surface for STM and AFM Experiments

该研究项目在分析和表面化学 该计划已被资助为探索性的小额赠款 Research. 这项研究将开发两种新的方法， 将DNA和其他生物分子附着到基底上， 随后通过扫描探针显微镜检查。 成功实施这些连接方法将 让扫描隧道和原子力的全部力量 显微镜应用于结构表征 生物分子和其他大分子系统。 这种结构 信息对于理解 生物分子反应及其与生命过程的关系。 %%% 将大的生物分子锚到基底上以 本研究将发展显微镜检查 项目 扫描显微镜探针与 正在研究的分子限制了这些的适用性， 大分子的强大方法。 本研究项目 承诺解决这些限制，从而实现更好的 了解这些生物学上重要的 分子。

This research project in the Analytical and Surface Chemistry Program has been funded as a Small Grant for Exploratory Research. The research will develop two novel methods for attaching DNA and other biomolecules to substrates for their subsequent examination by scanning probe microscopy. Successful implementation of these attachment methods will allow the full power of scanning tunneling and atomic force microscopy to be applied to the structural characterization of biomolecules and other macromolecular systems. Such structural information is essential to understanding the mechanisms of biomolecule reactions and their relation to life processes. %%% The ability to anchor a large biomolecule to a substrate for microscopic examination will be developed in this research project. The interaction of scanning microscopy probes with the molecule under study has limited the applicability of these powerful methods for large molecules. This research project promises to address these limitations, resulting in a better understanding of the structure of these biologically important molecules.