Novel C3 Symmetric Polypyrazole Ligands for Use in Enantioselective Transition-Metal-Mediated Transformations

用于对映选择性过渡金属介导的转化的新型 C3 对称聚吡唑配体

• 批准号: 9207152
• 负责人: William Tolman
• 金额: $ 19.2万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-07-15 至 1995-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9207152&HistoricalAwards=false
• 关键词: Novel; C3; Symmetric; Polypyrazole; Ligands

The focus of this research will be design and preparation of C3 symmetric metal reagents using optically active pyrazoles containing stereogenic centers adjacent to the metal binding nitrogen to a central B, P, C, or N-centered fragment. Complexes of Cu(I), Rh(III) and Fe(II and III) will then be prepared and used to promote a variety of important enantioselective conversions including cyclopropanations, 1,4-additions to enones, hydrosilylations, oxidations and cycloadditions. %%% With this award, the Synthetic Organic Program is supporting the research of Dr. William B. Tolman, a young investigator in the Department of Chemistry at the University of Minnesota. Professor Tolman will focus his work on projects that center on understanding the effect of three-fold symmetry on metal-mediated asymmetric induction and on developing new stereospecific synthetic processes.

本研究的重点是使用光学活性吡唑设计和制备 C3 对称金属试剂，该吡唑含有与金属结合氮到中心 B、P、C 或 N 中心片段相邻的立体中心。 然后将制备 Cu(I)、Rh(III) 和 Fe(II 和 III) 的配合物并用于促进各种重要的对映选择性转化，包括环丙烷化、烯酮的 1,4-加成、氢化硅烷化、氧化和环加成。 %%% 凭借这一奖项，合成有机项目正在支持明尼苏达大学化学系的年轻研究员 William B. Tolman 博士的研究。 托尔曼教授的工作重点是了解三重对称性对金属介导的不对称诱导的影响以及开发新的立体定向合成过程。