Novel C3 Symmetric Polypyrazole Ligands for Use in Enantioselective Transition-Metal-Mediated Transformations

本论文的研究重点是C3的设计和制备 使用光学活性吡唑的对称金属试剂 含有与金属结合相邻的立体中心 氮连接到中心B、P、C或N中心片段。 然后将Cu（I）、Rh（III）和Fe（II和III）的络合物 准备并用于促进各种重要的 对映选择性转化包括环丙烷化， 对烯酮的1，4-加成、氢化硅烷化、氧化和 环加成反应 %%% 有了这个奖项，合成有机计划正在支持 威廉B博士的研究。托尔曼，一个年轻的调查员， 明尼苏达大学化学系。 教授托尔曼将集中在他的工作项目的中心， 理解三重对称对 金属介导的不对称诱导和开发新的 立体定向合成方法。

The focus of this research will be design and preparation of C3 symmetric metal reagents using optically active pyrazoles containing stereogenic centers adjacent to the metal binding nitrogen to a central B, P, C, or N-centered fragment. Complexes of Cu(I), Rh(III) and Fe(II and III) will then be prepared and used to promote a variety of important enantioselective conversions including cyclopropanations, 1,4-additions to enones, hydrosilylations, oxidations and cycloadditions. %%% With this award, the Synthetic Organic Program is supporting the research of Dr. William B. Tolman, a young investigator in the Department of Chemistry at the University of Minnesota. Professor Tolman will focus his work on projects that center on understanding the effect of three-fold symmetry on metal-mediated asymmetric induction and on developing new stereospecific synthetic processes.