Enantioselective Reactivity Studies of Transition Metal Complexes of Optically Active Polypyrazole Ligands

光学活性聚吡唑配体过渡金属配合物的对映选择性反应性研究

• 批准号: 9632590
• 负责人: William Tolman
• 金额: $ 27万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9632590&HistoricalAwards=false
• 关键词: Enantioselective; Reactivity; Studies; Transition; Metal

The focus of this research is on the design and synthesis of new N-donor ligands and metal complexes of varying structure and symmetry to develop new stereoselective reactions and to study the scope and mechanism of selected enantioselective processes. Specific reactions to be studied include the catalytic oxidation of alkenes to allylic benzoates by perbenzoate esters using copper promoters, catalytic aziridination of alkenes by copper complexes, C-C bond forming reactions promoted by lanthanide complexes and C-H and C-C bond activations promoted by rhodium compounds. With this award, the Synthetic Organic Program is supporting the research of Dr. William B. Tolman of the Department of Chemistry at the University of Minnesota. Professor Tolman will focus his work on testing the efficacy of C3-symmetry in metal promoted enantioselective chemistry. Successful methodology will have an impact on synthesis in the pharmaceutical and agricultural industries.

本研究的重点是设计和合成不同结构和对称性的新型N-供体配体和金属络合物，以开发新的立体选择性反应，并研究选择的对映选择性过程的范围和机理。需要研究的具体反应包括在铜助剂作用下过苯甲酸酯催化烯烃氧化生成烯丙基苯甲酸酯，铜配合物催化烯烃的氮化反应，稀土配合物促进的C-C键形成反应，以及铑化合物促进的C-H键和C-C键的活化。通过这一奖项，合成有机计划支持明尼苏达大学化学系的威廉·B·托尔曼博士的研究。托尔曼教授将专注于测试C3对称性在金属促进的对映选择性化学中的有效性。成功的方法学将对制药和农业行业的合成产生影响。