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Repetitive DNA Sequences in Genome Organization of Phyllostomoid Bats: Test of a Molecular Model for Chromosomal Divergence

Repetitive DNA Sequences in Genome Organization of Phyllostomoid Bats: Test of a Molecular Model for Chromosomal Divergence
叶口蝙蝠基因组组织中的重复 DNA 序列:染色体分歧分子模型的测试
批准号:
9207597
负责人:
Robert Baker
金额:
$28.0万
依托单位:
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
1992
资助国家:
美国
项目状态:
已结题
起止时间:
1992-08-01 至 1995-07-31

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英文摘要
The design of this proposal brings strengths from molecular biology, cytogenetics, and cladistics to test the hypothesis that rapid chromosomal change and karyotypic stasis are primarily mediated at the molecular level by activity of repetitive sequences. We predict that taxa with radically reorganized karyotypes will have: 1) an abundance of copies and classes of rapidly evolving repetitive sequences;2) tandemly repeated sequences will have actively changed chromosomal fields among nonhomologous chromosomes; and 3) interspersed repeated sequences will have undergone changes in sequence and copy number due to transposition. Alternatively, lineages experiencing long periods of karyotypic stasis will have: 1) fewer classes of tandemly repeated sequences is low copy number; 2) tandemly repeated sequences restricted to specific chromosomal regions; and 3) interspersed elements will evolve at a rate similar to that of other neutral DNA, due to a lower rate of transposition. New World leaf-nosed bats were chosen because monophyly of taxa to be studied is well documented and they exhibit extremes in rates and types of karyotypic evolution. Methods of examination will include phylogenetic screening of genome libraries to determine the number and kind of rapidly evolving repetitive sequences. Chromosomal position and movement will be documented by cladistical analysis of data from in situ hybridization.
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NPGI: NSF Postdoctoral Fellowship in Biology FY 2013
  • 批准号:
    1306574
  • 项目类别:
    Fellowship Award
  • 资助金额:
    $21.6万
  • 财政年份:
    2013
  • 负责人:
    Robert Baker
  • 依托单位:
REU: Evolutionary Genetics and Dysgenesis in a Naturally Occurring Hybrid Zone in Peromyscus leucopus
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    9006797
  • 项目类别:
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  • 资助金额:
    $3.0万
  • 财政年份:
    1990
  • 负责人:
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The Role of the Third Deviatoric Stress Invariant in the Creep of Ice
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    8714983
  • 项目类别:
    Continuing Grant
  • 资助金额:
    $5.88万
  • 财政年份:
    1988
  • 负责人:
    Robert Baker
  • 依托单位:
Dynamics of a Hybrid Zone Between Chromosomal Races of the White-Footed Mouse, Peromyscus leucopus
  • 批准号:
    8600646
  • 项目类别:
    Continuing Grant
  • 资助金额:
    $13.0万
  • 财政年份:
    1986
  • 负责人:
    Robert Baker
  • 依托单位:
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