REU: Evolutionary Genetics and Dysgenesis in a Naturally Occurring Hybrid Zone in Peromyscus leucopus

REU：白足鼠自然发生的杂交区的进化遗传学和发育不全

• 批准号: 9006797
• 负责人: Robert Baker
• 金额: $ 3万
• 依托单位: Texas Tech University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-01 至 1992-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9006797&HistoricalAwards=false
• 关键词: REU; Evolutionary; Genetics; Dysgenesis; Naturally

Dr. Robert Baker, at Texas Tech University, is undertaking a multi-faceted study of a hybrid zone between two chromosomal races or subspecies of the white-footed deer mouse, Peromyscus leucopis, focused on hybrid dysgenesis. Preliminary data indicate that variation in DNA content and frequency of chromosomal aberrations is heightened in the hybrid zone. A goal of the research is to determine the genetic basis of this dysgenesis. This will be accomplished by controlled genetic crosses in the laboratory and the comparison of measures of dysgenesis between the progeny of these crosses and measures made in naturally occurring populations. The distribution of two DNA sequences, K18 and mys will also be examined in parental and hybrid animals. Mys is a retrovirus-like transposable element and k18 is a satellite DNA associated with heterochromatic regions of chromosomes. Dr. Baker hypothesizes a relationship between DNA content variation, chromosomal aberrations, and changes in the genomic distributions of mys and k18 sequences, all resulting from hybrid dysgenesis. This study will provide insight to the genetic changes that occur as new species are formed.

德克萨斯理工大学的罗伯特·贝克博士正在进行一项 两个染色体间杂种区的多方面研究 白足鹿鼠的一个小种或亚种 leucopis，专注于杂种发育不全。初步数据显示 DNA含量和染色体频率的变化 畸变在混合区中增强。的一个目标 研究的目的是确定这种发育不良的遗传基础。 这将通过控制遗传杂交来实现， 实验室和比较的措施， 这些杂交和措施的后代， 发生的人群。两个DNA序列K18的分布 还将在亲本和杂交动物中检查MYS。Mys 是一个逆转录病毒样转座因子，k18是一个随体 与染色体的异染色质区域有关的DNA。博士 贝克假设DNA含量变化， 染色体畸变和基因组的变化 mys和k18序列的分布，均由杂交产生 发育不良这项研究将提供深入了解遗传 新物种形成时发生的变化。