Radiochemistry Facility for Biomolecule Characterisation in Living Systems

该项目将提供一个微流体放射化学设备，填补新南威尔士州核心成像研究实验室网络的关键能力缺口。它将能够用短寿命放射性同位素标记新的生物分子，以便在活体中进行表征。该平台将支持多种多样的研究，包括结合特定蛋白质靶点的新型化学探针和纳米颗粒的开发和体内表征，下一代放射化学技术的开发，预测学习中大脑可塑性的研究机制，多模态图像分析的新方法的开发，以及对参与失调细胞网络的分子途径的理解。

This project will provide a microfluidic radiochemistry facility that fills a critical capability gap in the network of core imaging research laboratories in New South Wales. It will enable the labelling of novel biomolecules with short-lived radioisotopes for their characterisation in living subjects. This platform will enable research as diverse as the development and in-vivo characterisation of new chemical probes and nanoparticles that bind to specific protein targets, development of next generation radiochemistry technologies, investigating mechanisms of brain plasticity in predictive learning, developing novel methods for multi-modal image analysis, and understanding the molecular pathways involved in dysregulated cellular networks.