Radiochemistry Facility for Biomolecule Characterisation in Living Systems

用于生命系统中生物分子表征的放射化学设施

• 批准号: LE230100091
• 负责人: Prof Michael Kassiou
• 金额: $ 66.8万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-06-02 至 2024-06-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE230100091
• 关键词: Radiochemistry; Facility; Biomolecule; Characterisation; Living

This project will provide a microfluidic radiochemistry facility that fills a critical capability gap in the network of core imaging research laboratories in New South Wales. It will enable the labelling of novel biomolecules with short-lived radioisotopes for their characterisation in living subjects. This platform will enable research as diverse as the development and in-vivo characterisation of new chemical probes and nanoparticles that bind to specific protein targets, development of next generation radiochemistry technologies, investigating mechanisms of brain plasticity in predictive learning, developing novel methods for multi-modal image analysis, and understanding the molecular pathways involved in dysregulated cellular networks.

该项目将提供一个微流体放射化学设施，填补新南威尔士州核心成像研究实验室网络的关键能力缺口。它将能够用短寿命放射性同位素标记新的生物分子，用于在活体中进行表征。该平台将使研究多样化，如开发和体内表征新的化学探针和纳米颗粒，结合到特定的蛋白质靶点，开发下一代放射化学技术，研究预测学习中的大脑可塑性机制，开发新的多模态图像分析方法，并了解参与失调细胞网络的分子通路。