Radiochemistry Facility for Biomolecule Characterisation in Living Systems

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This project will provide a microfluidic radiochemistry facility that fills a critical capability gap in the network of core imaging research laboratories in New South Wales. It will enable the labelling of novel biomolecules with short-lived radioisotopes for their characterisation in living subjects. This platform will enable research as diverse as the development and in-vivo characterisation of new chemical probes and nanoparticles that bind to specific protein targets, development of next generation radiochemistry technologies, investigating mechanisms of brain plasticity in predictive learning, developing novel methods for multi-modal image analysis, and understanding the molecular pathways involved in dysregulated cellular networks.