Probing Anaesthetic Effects with New Functional Imaging Paradigms

点击翻译按钮获取中文摘要

This project seeks new insights into the effects of anaesthetics on brain function and repair. Anaesthesia is used in small-animal imaging to immobilise the animal, but in many cases the anaesthesia itself affects the neurophysiological parameters under study. It has also been shown that many anaesthetics enhance recovery after brain injury in small animals. This project plans to exploit a novel functional brain-imaging technique for conscious animals to gain new insights into the effects of anaesthetics on brain function and recovery from injury. The knowledge gained is expected to improve knowledge of anaesthetic action, guide future anaesthetic use in small animal imaging to improve the accuracy of image-derived research data, and help to clarify how anaesthetics confer neuroprotective effects in brain injury.