Electrochemical-Enzymatic Synthesis of Amino Acids

本研究的重点涉及一种方法的开发，该方法允许在含有酶、α-酮酸和氨源的水性介质中在电极处电化学还原氧化还原介体。还原的介体将酶还原至其活性状态，其又将与α-酮酸反应以提供光学活性形式的所需氨基酸。该工艺的优化可以为氨基酸的商业化生产提供一种经济上有竞争力、环境友好的方法。%化学部的合成有机计划和电力研究所（EPRI）共同支持Albert J. Fry博士和Susan B博士的研究。卫斯理大学的Sobolov和James M.康涅狄格大学的芬顿说。在NSF/EPRI电化学合成研究倡议下赞助的研究重点是开发用于合成α-氨基酸的电化学-酶促过程。

The focus of this research involves the development of a process which allows the electrochemical reduction of a redox mediator at an electrode in an aqueous medium containing an enzyme, an alpha-keto acid and an ammonia source. The reduced mediator will reduce the enzyme to its active state which will, in turn, react with the alpha-keto acid to afford the desired amino acid in optically active form. Optimization of the process could provide an economically competitive, environmentally benign method for the commercial production of amino acids. %%% With this award the Synthetic Organic Program of the Chemistry Division and the Electric Power Research Institute (EPRI) are co-supporting the research of Dr. Albert J. Fry and Dr. Susan B. Sobolov of Wesleyan University and Dr. James M. Fenton of the University of Connecticut. The focus of the research, sponsored under the NSF/EPRI initiative on Research in Electrochemical Synthesis, is the development of an electrochemical-enzymatic process for the synthesis of alpha-amino acids.