Electrochemical-Enzymatic Synthesis of Amino Acids

本研究的重点是开发一种过程，该过程允许在含有酶，α -酮酸和氨源的水介质中电极上电化学还原氧化还原介质。还原的介质将酶还原到其活性状态，这将反过来与α酮酸反应以提供所需的光学活性形式的氨基酸。该工艺的优化可为氨基酸的商业化生产提供一种具有经济竞争力、环境友好的方法。通过这个奖项，化学部门的合成有机项目和电力研究所（EPRI）共同支持卫斯理大学的Albert J. Fry博士和Susan B. Sobolov博士以及康涅狄格大学的James M. Fenton博士的研究。这项研究由NSF/EPRI电化学合成研究计划资助，研究重点是开发一种用于合成α -氨基酸的电化学酶促过程。

The focus of this research involves the development of a process which allows the electrochemical reduction of a redox mediator at an electrode in an aqueous medium containing an enzyme, an alpha-keto acid and an ammonia source. The reduced mediator will reduce the enzyme to its active state which will, in turn, react with the alpha-keto acid to afford the desired amino acid in optically active form. Optimization of the process could provide an economically competitive, environmentally benign method for the commercial production of amino acids. %%% With this award the Synthetic Organic Program of the Chemistry Division and the Electric Power Research Institute (EPRI) are co-supporting the research of Dr. Albert J. Fry and Dr. Susan B. Sobolov of Wesleyan University and Dr. James M. Fenton of the University of Connecticut. The focus of the research, sponsored under the NSF/EPRI initiative on Research in Electrochemical Synthesis, is the development of an electrochemical-enzymatic process for the synthesis of alpha-amino acids.