Stability of HIV Viral RNA in Environmental Conditions

HIV 病毒 RNA 在环境条件下的稳定性

• 批准号: 9208837
• 负责人: Morteza Abbaszadegan
• 金额: $ 5万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-03-01 至 1993-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9208837&HistoricalAwards=false
• 关键词: Stability; HIV; Viral; RNA; Environmental

This is an award to support research to determine the stability of viral nucleic acids homologous to the Human Immunodeficiency Virus (HIV) under differing environmental conditions as encountered in primary, secondary and final effluents from domestic wastewater treatment plants, tap water and other aqueous fluids using the polymerase chain reaction method for detection of viral ribonucleic acid in samples being examined. The investigators plan on determining the duration of the persistence of this nucleic acid after the virus has lost its ability to infect cell cultures. This proposal was submitted to NSF under conditions outlined in NSF 89-85, Small Grants for Exploratory Research (SGER). Results of prior studies reporting the presence of nucleic acids "homologous" to the Human Immunodeficiency Virus (HIV) in wastewater concentrates suggest the importance of determining whether these nucleic acids are degraded after the ability of this virus to infect cell cultures has been lost. This, in turn, would assist in assessing the potential of infectious viral transmission through environmental media.

这是一个奖项，以支持研究，以确定 与人同源的病毒核酸的稳定性 不同环境下的免疫缺陷病毒（HIV） 在小学、中学和高中阶段遇到的情况 生活污水处理厂流出物，自来水 使用聚合酶链的水和其它含水流体 检测病毒核糖核酸的反应方法 正在检查的样品。 调查人员计划 确定这种持续的持续时间， 当病毒失去了感染的能力后， 感染细胞培养物。 该提案提交给NSF的条件是 NSF 89-85，探索性研究的小额赠款 研究（SGER）。 先前报告的研究结果 存在与人类“同源”的核酸 浓缩废水中的免疫缺陷病毒（HIV） 建议确定这些是否重要 在这种病毒的能力之后， 感染细胞培养的能力已经丧失 这反过来又 将有助于评估潜在的传染性 病毒通过环境媒介传播。