Partnership to Assess Viral and Immune Landscape Intersections with ONcology for People Living with HIV (PAVILION)

与肿瘤学合作评估艾滋病病毒感染者的病毒和免疫景观交叉点 (PAVILION)

• 批准号: 10598373
• 负责人: Margaret Ziona Borok
• 金额: $ 124.45万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-03 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598373
• 关键词: AIDS related cancer; Address; Africa; Africa South of the Sahara; Anatomy; Award; Cancer Burden; Cancer Control; Cancer Etiology; Cervical; Clinical; Collaborations; Conjunctival Neoplasms; Conjunctival Squamous Cell Carcinoma; Country; Data; Detection; Development; Disease; Educational workshop; Etiology; Faculty; Fostering; Future; Germany; Goals; HIV; HIV Infections; HIV/AIDS; High Prevalence; Home; Human Herpesvirus 4; Human Papilloma Virus Vaccination; Human Papilloma Virus-Related Malignant Neoplasm; Human Papillomavirus; Immune; Immunosuppression; Infection; Infrastructure; Institution; Intervention; Laboratories; Lead; Leadership; Life; Life Expectancy; Longitudinal Studies; Malignant Neoplasms; Malignant neoplasm of anus; Malignant neoplasm of cervix uteri; Malignant neoplasm of penis; Malignant neoplasm of vulva; Medical; Mentors; Mentorship; Morbidity - disease rate; Oncogenic Viruses; Oncology; Outcome; Persons; Pilot Projects; Premature Mortality; Prevention; Productivity; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Role; Site; South Africa; Sustainable Development; Therapeutic; Training Programs; Translations; Treatment outcome; United States National Institutes of Health; Viral; Virus; Woman; Zimbabwe; anticancer research; antiretroviral therapy; cancer risk; cancer therapy; co-infection; comorbidity; data management; design; experience; high risk; improved outcome; infection related cancer; innovation; leadership development; lectures; low and middle-income countries; malignant oropharynx neoplasm; men; mortality; novel; prevent; programs; screening; statistics; success; targeted treatment; tumor; tumor-immune system interactions; virus related cancer

PROJECT SUMMARY – OVERALL The partnership center, entitled Partnership to Assess Viral and Immune Landscape Intersections with Oncology (PAVILION) for People Living with HIV Program will bring together experienced research sites and world- renowned HIV, human papillomavirus (HPV), Epstein Barr Virus (EBV), and cancer researchers to offer a novel contribution to the HIV-Associated Malignancies Research Center network. The PAVILION theme is research of understudied, virus-associated tumors that disproportionately impact men and women living with HIV in sub-Saharan Africa (SSA). SSA remains home to two thirds of people living with HIV (PLWH). HIV-related immunosuppression results in an inability to control viruses and therefore a higher risk of virus-associated cancer, even among PLWH on effective antiretroviral therapy. The increasing life-expectancy of PLWH compounds this cancer risk as cancer is now a leading cause of mortality among PLWH in both high and low resource countries. Furthermore, PLWH experience poorer cancer treatment outcomes. Despite this, few studies of cancer etiology and cancer outcomes among PLWH in LMICs have been conducted, with little focus on HPV cancers at extra-cervical anatomic sites and very few studies of a suspected viral etiology for conjunctival tumors. PAVILION will therefore focus on the full range of cancers caused by HPV (anal, cervical, oropharyngeal, penile, and vulvar cancers) and the potential role of EBV in conjunctival squamous cell carcinoma - cancers that are disproportionality higher among PLWH, and which result in substantial morbidity and mortality. The overall goal of PAVILION is to provide the data necessary to inform prevention and therapeutic strategies to reduce the burden of cancers among PLWH in SSA. PAVILION includes partners in South Africa and Zimbabwe, multiple institutions in the US, and the DKFZ in Germany. Notably, Zimbabwe and South Africa have among the highest prevalence of HIV in Africa and have a rapidly increasing cancer burden that is largely comprised of infection-associated cancers. As a partnership, we have long standing collaborations, outstanding research leadership, mutual prioritization of the cancers to study, and institutional and consortium experience that will facilitate translation of scientific findings to achieve our goal. Specific Aims supporting this goal are: Aim 1: Establish a multi-national partnership with research infrastructure (Administrative & Coordinating, Central Laboratory, and Data Management & Statistics Cores) to conduct collaborative, innovative, and impactful research that advances prevention and treatment of infection-related cancers among PLWH in SSA Aim 2: Understand the fraction of tumors attributable to specific oncogenic viruses (i.e., HPV, EBV), the characterization of the immune microenvironment of tumors unique to the setting of HIV, and a more complete understanding of clinical outcomes for PLWH and cancer in SSA (Projects 1 and 2) Aim 3: Build capacity through active mentorship and training programs (Administrative & Coordinating and Developmental Cores) for early stage and junior faculty at partnership institutions

项目概要-总体 该合作中心名为评估病毒和免疫景观与肿瘤学交叉点的合作伙伴关系， （PAVILION）艾滋病病毒感染者项目将汇集经验丰富的研究地点和世界各地的 著名的艾滋病毒，人乳头瘤病毒（HPV），爱泼斯坦巴尔病毒（EBV），和癌症研究人员提供一种新的 艾滋病毒相关肿瘤研究中心网络的贡献。展馆的主题是研究 研究不足的病毒相关肿瘤，不成比例地影响男性和女性艾滋病毒感染者 在撒哈拉以南非洲（SSA）。撒哈拉以南非洲仍然是三分之二艾滋病毒感染者的家园。hiv相关 免疫抑制导致无法控制病毒，因此病毒相关性感染的风险更高。 即使是在接受有效抗逆转录病毒治疗的艾滋病毒携带者中。艾滋病毒/艾滋病感染者预期寿命的增加 由于癌症现在是艾滋病病毒携带者死亡的主要原因， 资源国。此外，PLWH经历较差的癌症治疗结果。尽管如此， 在中低收入国家的艾滋病毒携带者中进行了癌症病因学和癌症结局的研究， 宫颈外解剖部位的癌症和结膜肿瘤的疑似病毒病因学研究很少。 因此，PAVILION将专注于HPV引起的各种癌症（肛门、宫颈、口咽、阴茎、 和外阴癌）以及EB病毒在结膜鳞状细胞癌中的潜在作用， 艾滋病毒/艾滋病感染者的发病率和死亡率较高。 PAVILION的总体目标是为预防和治疗策略提供必要的数据 减少撒哈拉以南非洲艾滋病毒携带者和艾滋病患者的癌症负担。PAVILION包括南非的合作伙伴， 津巴布韦，美国的多个机构，以及德国的DKFZ。值得注意的是，津巴布韦和南非 非洲艾滋病毒流行率最高的国家之一，癌症负担迅速增加， 由感染相关的癌症组成。作为合作伙伴，我们有着长期的合作关系， 研究领导力，相互优先研究癌症，以及机构和联盟经验 这将有助于科学发现的转化，以实现我们的目标。支持这一目标的具体目标是： 目标1：建立具有研究基础设施的多国伙伴关系（行政和协调， 中心实验室，数据管理和统计核心）进行协作，创新， 促进SSA中PLWH感染相关癌症预防和治疗的有效研究 目的2：了解可归因于特定致癌病毒的肿瘤比例（即，HPV、EBV）， 表征肿瘤的免疫微环境独特的艾滋病毒的设置，和一个更完整的 了解SSA中PLWH和癌症的临床结局（项目1和2） 目标3：通过积极的指导和培训方案（行政和协调以及 发展核心）针对合作机构的早期和初级教师