Antisedimentation Dialysis: Fundamentals and Applications in Membrane Characterization, Fractionation of Macrosolutes,and Simulation of Microgravity

抗沉降透析：膜表征、大溶质分级和微重力模拟的基础知识和应用

• 批准号: 9210277
• 负责人: Ludwig Nitsche
• 金额: $ 10万
• 依托单位: University of Illinois at Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-06-01 至 1995-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9210277&HistoricalAwards=false
• 关键词: Antisedimentation; Dialysis; Fundamentals; Applications; Membrane

This proposal studies a dialysis flow cell which has been formulated by the PI and is termed an "antisedimentation dialysis system." In this system, two streams containing solute particles and solvent flow countercurrently in channels which are placed on opposite sides of a semipermeable dialysis membrane. The exits of each channel contain a barrier membrane which allows only passage of the solvent. When the dialysis membrane does not permit passage of solute, strong solute gradients in the flow direction develop as solute piles up at the flow exit barriers. For a semipermeable dialysis membrane, solute transport reduces these gradients and causes the concentration to become more uniform. This process can be used to measure hindered diffusion coefficients of solute through the pores of the semipermeable dialysis membrane barrier, and more importantly, can be used in fractionating solutes.

该建议研究了一种透析流动池， 由PI制定，并被称为“抗沉降剂 透析系统“在这个系统中，两个流包含 溶质颗粒和溶剂在通道中逆流流动 它们被放置在半渗透性透析的相对侧上 膜的 每个通道的出口都包含一个屏障 膜，其仅允许溶剂通过。 当 透析膜不允许溶质通过，强 沿流动方向的溶质梯度发展为溶质堆 在气流出口屏障处。 对于半透性透析 膜，溶质运输降低这些梯度，并导致 浓度变得更加均匀。 这个过程可以 用于测量溶质的受阻扩散系数 通过半渗透透析膜的孔 屏障，更重要的是，可以用于分馏 溶质。