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Errant epitopes from arginine methylated SARS-CoV-2 proteins predisposing to autoimmune diseases.

Errant epitopes from arginine methylated SARS-CoV-2 proteins predisposing to autoimmune diseases.
精氨酸甲基化 SARS-CoV-2 蛋白的错误表位易患自身免疫性疾病。
批准号：
448992
负责人：
Richard Stphane
金额：
$22.53万
依托单位：
Lady Davis Institute for Medical Research (Mtl)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2021
资助国家：
加拿大
项目状态：
已结题
起止时间：
2021-04-01 至 2022-04-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=448992&lang=en
关键词：
Antigenic Epitopes Arginine Methylation Nucleocapsid Post-Translational Modification Prmt Inhibitors Prmt1 Variants Viral Replication

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Drugs that can inhibit SARS-CoV-2 replication are urgently needed besides vaccines. The drugs can target the variants while vaccines provide limited immunity against only 1 protein, namely Spike. Our data show that viral proteins are modified post-transla
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