Modeling of Transient Processes in Cell Adhesion

该项目的重点是 发展一个数学 细胞粘附模型。 这 该项目将扩展现有模式 通过结合瞬态 细胞分裂过程中发生的过程 粘附到模型中。 的 研究者将获得分析 和数值解 各种细胞粘附问题 包括自发生长的 粘连面积，强力的 分离贴壁细胞，和 粘附和分离 流动的条件。 的 研究人员还将进行一项 系统参数分析 模型变量和验证 通过比较模型， 实验结果的结果。 这个项目很重要，因为 结果应该有助于 设计和改进 粘附依赖性生物医学和 生物处理设备 的 数学结构， 使用，移动边界问题， 需要了解其他 工艺，例如沉积， 熔化、凝固和细胞 运动性，因此， 研究应该推动 研究一个广泛的 系列工程 问题

The focus of this project is the development of a mathematical model for cell adhesion. This project will extend present models by incorporating the transient processes that occur during cell adhesion into the model. The investigator will obtain analytical and numerical solutions for a variety of cell adhesion problems including spontaneous growth of adhesion area, forcible separation of adherent cells, and adhesion and separation under the condition of flow. The researcher also will conduct a systematic parametric analysis on model variables and validate the model by comparison of the results of experimental outcomes. This project is important since the results should help in designing and improving adhesion-dependent biomedical and bioprocessing devices. The mathematical structure that will be used, the moving boundary problem, is needed to understand other processes, such as deposition, melting, solidification, and cell motility, and therefore this research should advance the methodology needed to study a broad range of engineering problems.