Sensory Modulation of Motor Patterns

运动反应可以被传入的感觉信息所改变。 在这个奖项中，Kiisa Nishikawa博士将研究 大脑使用传入的感觉输入来修改运动输出， 它变得适合于当前的环境。的途径 要解决这个基本问题， 作为一个模型系统。关于神经回路， 与这些反应相关，以及关于 与猎物相关的刺激。 然而，进程 运动输出与感觉输入相匹配的方法仍然有待于 阐明。运动反应需要准确的感觉 物体移动时的识别和精确定位 穿过视野一旦这些认知过程和 定位已经进行，大脑必须产生一个 适当的运动反应，在正确的方向定向，在 正确的距离，并且响应必须在一段时间内发生 短到足以确保捕获猎物。在这些实验中， 与捕获猎物有关的感觉反馈系统将是 其特征在于（1）描述感觉感受器的解剖学， 以及它们的中枢投射， 免疫组化染色;（2）确定模式 在正常进食期间使用细胞外 背根和周围神经记录;（3）阐明 感觉输入如何通过传入阻滞调节运动输出， 传入刺激实验喂食运动模式将是 研究使用高速摄像，肌电图和 来自外周神经的细胞外记录。 本研究将 有助于理解适应性的神经基础 反应和感觉运动整合。

Motor responses can be modified by incoming sensory information. In this award, Dr. Kiisa Nishikawa will study the way in which the brain uses incoming sensory input to modify motor output so that it becomes appropriate to its current context. The approach for solving this fundamental problem will use anuran feeding responses as a model system. Much is already known about the neural circuits associated with these responses, and about sensory processing of stimuli associated with the prey object. However, the processes by which motor output is matched to sensory input remain to be elucidated. The motor responses require accurate sensory recognition and precise localization of the objects as they move through the visual field. Once these processes of recognition and localization have been carried out, the brain must produce an appropriate motor response oriented in the correct direction at the correct distance, and the response must occur within a time period short enough to insure prey capture. In these experiments, the sensory feedback systems associated with prey capture will be characterized by (1) describing the anatomy of sensory receptors and their central projections using neuronal tracing and immunohistochemical staining; (2) determining the pattern of sensory activity during normal feeding using extracellular recording from dorsal roots and peripheral nerves; (3) elucidating how sensory input modulates motor output using deafferentation and afferent stimulation experiments. Feeding motor patterns will be studied using high-speed videography, electromyography and extracellular recording from peripheral nerves. This study will contribute to an understanding of the neural basis of adaptive responses and sensory-motor integration.