Sub-Threshold Receptive Fields of Sensory Neocortex

感觉新皮质的亚阈值感受野

• 批准号: 9213451
• 负责人: Harvey Swadlow
• 金额: $ 4万
• 依托单位: University of Connecticut
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-01 至 1995-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9213451&HistoricalAwards=false
• 关键词: Sub; Threshold; Receptive; Fields; Sensory

A novel method is being developed for study of sub-threshold synaptic events that occur within individual neurons in the awake mammalian brain. Unlike traditional methods which require impalement and resultant damage to a nerve cell by an intracellular microelectrode, the present method uses an electrode which is extracellular. Far less cellular damage results, therefore, and sub-threshold synaptic events can be studied for very long periods of time. The method entails passing extracellular current pulses through a recording microelectrode and measuring the threshold of the neuron under study to this direct electrical stimulation. This research explores the application of this new method to two problem areas in cortical neurophysiology: (1) the analysis of sub- threshold receptive fields and components of receptive fields in sensory neocortex, and (2) the analysis of sub-threshold synaptic inputs to neurons studied with chronically implanted electrodes over very long periods of time. This research will contribute to a better understanding of the cortical neuronal substrates of sensory perception and the dynamic mechanisms by which the properties of individual neurons are modified by experience over long periods of time.

提出了一种新的亚阈值研究方法 在清醒时单个神经元内发生的突触事件 哺乳动物的大脑 与传统方法不同， 刺入和由此引起的神经细胞损伤 微电极，本方法使用的电极， 细胞外的 因此，细胞损伤要小得多， 阈下突触事件可以被研究很长时间 时间了 该方法需要通过细胞外电流脉冲 通过记录微电极， 被研究的神经元受到这种直接电刺激。 本研究探讨了这种新方法的应用，以两个 皮质神经生理学的问题领域：（1）分析亚- 阈值感受野和感受野的组成部分 感觉新皮层;（2）阈下突触分析 通过长期植入电极研究神经元的输入， 很长一段时间 这项研究将有助于 更好地理解皮层神经元的感觉基底 感知和动态机制的属性， 个体神经元在长时间的经历中被修改， 时间