The interplay of apoptosis proteins, mitochondria and premature senescence in beta-cell fate and diabetes

细胞凋亡蛋白、线粒体和早衰在β细胞命运和糖尿病中的相互作用

• 批准号: 450487
• 负责人: Luciani Dan S
• 金额: $ 61.02万
• 依托单位: BC Children's Hospital Research Institute
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-09-01 至 2026-09-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=450487&lang=en
• 关键词: Apoptosis; Autophagy / Mitophagy; Bcl-2 Family Proteins; Beta-Cell Biology; Cellular Stress; Diabetes; High Content Imaging; Islet Biology; Mitochondrial Morphology And Function; Senescence

Diabetes is a serious disease in which high levels of blood sugar (glucose) damage the body and markedly shortens life-span. Glucose is normally kept low by the hormone insulin, which is released from beta-cells in the pancreas. Diabetes develops, in larg

糖尿病是一种严重的疾病，其中高水平的血糖（葡萄糖）损害身体并显着缩短寿命。葡萄糖通常由胰岛素保持在低水平，胰岛素是从胰腺中的β细胞释放出来的。糖尿病的发展，