Sulfide Detoxification Mechanisms of the Epithelia of Urechis Caupo

硫化氢是一种剧毒的工业废物， 仅去年一年就在加州发生多起死亡事件 这些 事件涉及洛杉矶的一家纸张回收厂 被有毒的硫化物气体和铁路泄漏的 威百亩钠导致异硫氰酸甲酯的释放， 硫化氢气体作为分解产物。 拟建项目 研究硫化物解毒的外周组织， 海洋蠕虫 虽然我们以前的研究适应低 氧气和硫化物表明这种动物在体内 体内液体，身体组织如何被保护的问题 或耐受有毒硫化物的问题仍然没有答案。 初步数据 表明外周组织具有明显的硫化物 解毒或耐受机制，包括 硫化物氧化体和共生细菌。 的结合或 硫化物转化为无毒形式的硫， 外部身体组织。 阐明这些外围防御 这些机制将为实现 了解硫化物中毒的耐受性和治疗。 此外，提案中概述的研究将有助于 硫化物代谢的成熟领域， 动物的解毒 该研究项目的资金将 继续帮助本科生和研究生 学生，并为研究做出重大贡献 在旧金山弗朗西斯科州立大学的环境。

Hydrogen sulfide is an extremely toxic industrial waste responsible for a number of deaths in California in the last year alone. These incidents involved a paper recycling factory in Los Angeles enveloped by a cloud of toxic sulfide gas and a railroad spill of metam sodium resulting in the release of methyl isothiocyanate and hydrogen sulfide gas as breakdown products. The proposed project investigates sulfide detoxification in the peripheral tissues of a marine worm. Although our previous studies of adaptations to low oxygen and sulfide indicate that this animal detoxifies sulfide in internal fluids, the question of how the body tissues are protected or tolerate toxic sulfide remains unanswered. Preliminary data suggest that the peripheral tissues possess distinct sulfide detoxification or tolerance mechanisms, including the presence of sulfide-oxidizing bodies and symbiotic bacteria. The binding or transformation of sulfide to nontoxic forms of sulfur in the external body tissues. Elucidation of these peripheral defense mechanisms will provide a significant contribution to the understanding of tolerance and treatment of sulfide poisoning. Additionally, the studies outlined in the proposal will contribute to the well established field of sulfide metabolism and detoxification in animals. Funding of the research project would result in continued assistance to undergraduate and graduate students and be a significant contribution to the research environment at San Francisco State University.