SGER: Differential Expression of Hypodynamic Genes in Hibernating vs. Non-hibernating Animals

SGER：冬眠与非冬眠动物中动力不足基因的差异表达

• 批准号: 9220303
• 负责人: Barbara Horwitz
• 金额: $ 2万
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-11-01 至 1994-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9220303&HistoricalAwards=false
• 关键词: SGER; Differential; Expression; Hypodynamic; Genes

The ultimate goal of this proposal is to identify the molecular basis underlying preparation for and induction of hibernation in mammals. This initial approach involves identification of hypothalamic genes whose expression is changed in hamsters before vs during a bout of hibernation. This approach is based on the hypothesis that induction of hibernation in mammals results from altered neural/neurosecretory signaling to central and/or peripheral regulators/effectors of thermogenesis and/or heat loss AND that these alterations in signalling reflect altered gene expression. While this hypothesis is reasonable considering the regulatory role played by the hypothalamus and the changes in thermogenic tissues such as brown fat that considerable difficulty in detecting the hibernation process.

这项提案的最终目标是确定分子 准备和诱导冬眠的基础 哺乳动物这一初步做法涉及确定 下丘脑基因，其表达在仓鼠中改变， vs在一轮冬眠期间。该方法基于 哺乳动物冬眠的原因是 改变的神经/神经分泌信号传导到中枢和/或 产热和/或热损失的外周调节因子/效应因子 这些信号的改变反映了基因的改变， 表情虽然这一假设是合理的， 下丘脑所起的调节作用以及 产热组织，如棕色脂肪， 检测休眠过程。