Allylic Cation Cycloadditions

烯丙基阳离子环加成

• 批准号: 9220679
• 负责人: Michael Harmata
• 金额: $ 21.28万
• 依托单位: University of Missouri-Columbia
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-01-15 至 1996-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9220679&HistoricalAwards=false
• 关键词: Allylic; Cation; Cycloadditions

The focus of this research will be on intramolecular 3+2 and 4+3 cycloaddition recations of allyl cations with dienes. Alkoxyallylic alcohols, cyclopropane hemiacetals and allylic sulfoxides will be used as progenitors of allylic cations. A detailed study of regioselectivity and relative stereochemistry will be made in the context of the synthesis of fused 6,7 and 6,5 bicyclic ring systems. %%% With this Renewal award, the Synthetic Organic Program is supporting the research of Professor Michael Harmata of the Department of Chem,istry at the University of Missouri, Columbia. Dr. Harmata will focus his work on developing a class of reactions known as cycloadditions for the purpose of constructing compounds containing 5,6 and 7-membered rings, structures often occuring in important natural products.

本研究的重点将是分子内3+2和 烯丙基阳离子与二烯的4+3环加成反应。 烷氧基烯丙醇、环丙烷半缩醛和烯丙基 亚砜将用作烯丙基阳离子的前体。 一 区域选择性和相对立体化学的详细研究 将在合成稠合6，7和 6，5双环环系。 %%% 有了这个更新奖，合成有机计划是 支持迈克尔·哈玛塔教授的研究， 密苏里州大学化学系， 哥伦比亚。 Harmata博士将把工作重点放在开发一种 一类反应称为环加成的目的， 构建含有5、6和7元环的化合物， 常见于重要的天然产物中。