Intramolecular 4+3 Cycloadditions

Michael Harmata博士在该部门的研究计划 密苏里-哥伦比亚大学的化学系 由有机合成计划支持。 校长 研究人员将研究范围，立体化学和 这是一种称为4+3环加成的反应机制。的 由于缺乏有关这一过程的数据， 研究新的方法， 重要的含环化合物的构建。 这项工作的目标是建立有效性和范围， 的分子内4+3环加成二烯与 烷氧基烯丙基阳离子，特别是衍生自 相应的烯丙基砜和应用新兴的 方法的合成结构有趣， 重要分子

The research program of Dr. Michael Harmata in the Department of Chemistry at the University of Missouri-Columbia will be supported by the Organic Synthesis Program. The principal investigator will study the scope, stereochemistry and mechanism of a reaction class known as 4+3 cycloadditions. The paucity of data regarding the process make it a fertile area for the investigation of new methodology leading to the construction of important ring-containing compounds. The goals of the work are to establish the efficacy and scope of the intramolecular 4+3 cycloaddition of dienes with alkoxyallylic cations, particularly those derived from the corresponding allylic sulfones and to apply the emerging methodology to the synthesis of structurally interesting and important molecules.