Presidential Young Investigator: Synthesis and Reactivity of Vanadium(II) Coordination Compounds

总统青年研究员：钒(II)配位化合物的合成和反应性

• 批准号: 9221682
• 负责人: William Armstrong
• 金额: $ 7.43万
• 依托单位: Boston College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-15 至 1995-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9221682&HistoricalAwards=false
• 关键词: Presidential; Young; Investigator; Synthesis; Reactivity

This Presidential Young Investigator Award from the Inorganic, Bioinorganic, and Organometallic Chemistry Program supports research in biologically relevant inorganic chemistry. The emphasis of the project is the elucidation of the role of metal ions in important biological transformations. Of particular interest is the participation of transition metal ions in the terminal steps of the reduction of dioxygen by cytochrome oxidase and the evolution of oxygen by the photosynthetic apparatus. Small molecule analogs of the metal centers of these and other metalloproteins, especially manganese-containing proteins, will be synthesized and characterized. The general strategy involves the design and synthesis of organic ligands, preparation and purification of their complexes with transition metals, and thorough characterization of such systems by a variety of structural, magnetic, and spectroscopic techniques. In addition to the systems mentioned above, others of interest include the magnetically-coupled siroheme and diron-sulfur cluster in sulfite reductase, and the participaton of nickel in hydrogenase and methanogenesis activity. Finally, the role of low valent vanadium in catalyzing the conversion of dinitrogen to ammonia and hydrazine will be explored. Comparison of the spectroscopic and chemical properties of the model compounds is expected to yield valuable insight into the detailed workings of the modeled biological systems.

这位来自无机物的总统青年研究者奖， 生物无机和有机化学计划支持 生物学相关无机化学研究。 的 该项目的重点是阐明金属的作用 离子在重要的生物转化中的作用 特别 感兴趣的是过渡金属离子参与 细胞色素还原分子氧的终末步骤 氧化酶和光合作用释放氧气 设备. 金属中心的小分子类似物 这些和其他金属蛋白，特别是 含锰蛋白质，将被合成， 表征了 总体战略包括设计和 有机配体的合成、制备和纯化 它们与过渡金属的络合物， 通过各种结构， 磁性和光谱技术。 除了有 上述系统，其他感兴趣的包括 磁耦合siroheme和diron-sulfur簇 亚硫酸盐还原酶，镍的参与， 氢化酶和甲烷生成活性。 最后， 低价钒催化二氮转化 氨和联氨的反应。 比较 光谱和化学性质的模型化合物是 预计将产生有价值的深入了解详细的运作 模拟的生物系统。