Studies in Asymmetric Synthesis

该奖项是卡雷拉博士的启动补助金增量 化学博士后奖学金。设计和合成 结构明确的稀土配合物， 杂Diels-桤木环加成反应的不对称催化 将进行反应。研究的系统包括 非手性醛与官能化二烯的反应。 亲二烯体上的保护基团将提供第二个 与络合物的接触点，以提高选择性 一个非对映体过渡态的形成。这些 空间效应将导致产物选择性增加。 %%% Diels桤木反应在不同的反应条件下是非常通用的。 各种各样的分子。这个提议 我将研究使反应更进一步的方法。 选择性的结果将导致新的合成 其中一些分子可能具有重要的生理功能 特性.

This award is the starter grant increment of Dr. Carreira's Postdoctoral Fellowship in Chemistry. The design and synthesis of structurally well-defined rare earth complexes for the asymmetric catalysis of the hetero-Diels-Alder cycloaddition reaction will be carried out. Systems to be studied include the reactions of achiral aldehydes with funcionalized dienes. Protecting groups on the dienophile will provide a second contact point with the complex to enhance the selectivity of the formation of one diastereomeric transition state. These steric effects will lead to increased product selectivity. %%% The Diels Alder reaction is very versatile in the different kinds of molecules that can be prepared by it. This proposal will study means by which the reaction can be made more selective. The results will lead to the synthesis of new molecules some of which could have important physiological properties.