Catalytic, Enantioselective Mukaiyama Aldol Addition Reaction: The Development of Chiral Ti (IV) Complexes with Tri-and Tetra-dentate Ligands

催化、对映选择性向山羟醛加成反应：三齿和四齿配体手性 Ti (IV) 配合物的开发

• 批准号: 9420971
• 负责人: Erick Carreira
• 金额: $ 9.85万
• 依托单位: California Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-08-01 至 1997-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9420971&HistoricalAwards=false
• 关键词: Catalytic; Enantioselective; Mukaiyama; Aldol; Addition

The focus of this research is the use of Ti(IV) complexes containing Schiff-base tridentate ligands to carry out enantioselective aldol additions. Ligands will be based upon 2-amino-2'-hydroxy-1,1'-binapthyl and 2,2'-diaminobinapthyl scaffolds upon which the the counterion and nature of the salicylimine are varied. Enantioselective aldol addition reactions of acetate, propionate, crotonate and ketone derived silyl enol ethers will be explored. The catalytic methodology will lead to the production of optically active beta-hydroxy esters and delta-hydroxy-alpha, beta-unsaturated esters. With this award, the Synthetic Organic Program is supporting the research of Dr. Erick M. Carreira of the Department of Chemistry at the Califonia Institute of Technology. Professor Carreira will focus his work on the development of catalytic methodology for the the formation of carbon-carbon bonds. The optically active products are useful intermediates for the preparation of stereochemically complex systems that have important biological properties.

本研究的重点是使用Ti（IV）配合物， 席夫碱三齿配体进行对映选择性羟醛缩合反应 的增订条文 配体将基于 2-氨基-2 '-羟基-1，1'-联萘和2，2 '-二氨基联萘支架 水杨酰亚胺的结构和性质随其变化。 乙酸酯，丙酸酯， 将探索巴豆酸酯和酮衍生的甲硅烷基烯醇醚。 的 催化方法将导致光学活性的生产 β-羟基酯和δ-羟基-α，β-不饱和酯。 有了这个奖项，合成有机计划正在支持这项研究 埃里克·M博士加州大学化学系的卡雷拉说， 理工学院 卡雷拉教授将把他的工作重点放在 发展催化方法， 碳碳键 光学活性产物是有用的， 用于制备立体化学复合体系的中间体 具有重要的生物学特性。