Specific Complexation of Metal Oxo Cations

该奖项继续支持加州大学伯克利分校化学系Kenneth N.Raymond博士对氧金属阳离子选择性结合的研究。将开发用于月桂醇和钒基等阳离子的择形配体。这些配体将被设计为通过正常的配位结合来稳定高氧化态金属中心，同时加入氢键供体以与氧离子相互作用。初步结果表明，如果能够开发出小心取向的刚性配体，氢键相互作用可能是显著的。待研究的配体包括氨基羧酸盐、邻苯二酚酰胺、邻苯二酚苯酚和酰胺酸盐。所得化合物将通过晶体结构分析、振动光谱、电化学和溶液热力学研究进行表征。将对配体的特异性和络合能力进行测试。这个项目的目标是开发有效和选择性的金属氧离子清除剂。将尝试一种新的方法，涉及以一种方式将氢原子定位在络合剂上，以结合到与金属相关联的氧基团。这项研究对分离方法有影响，包括对放射性废物中发现的镧系元素和榄系元素家族成员的分离方法。

This award provides continuing support for the study of selective binding of oxo metal cations by Dr. Kenneth N. Raymond of the Department of Chemistry, University of California, Berkeley. Shape selective ligands for cations such as osmyl and vanadyl will be developed. These ligands will be designed to stabilize the high oxidation state metal center through normal coordinate binding, while at the same time incorporating hydrogen bond donors for interaction with the oxo cation. Preliminary results show that the hydrogen bonding interaction can be significant if carefully oriented, rigid ligands can be developed. Ligands to be investigated include aminocarboxylates, catechol amides, catechol phenols and amidates. The resulting compounds will be characterized by crystal structure analysis, vibrational spectroscopy, electrochemistry, and solution thermodynamics studies. Both the specificity and complexing ability of the ligands will be tested. %%% The goal of this project is to develop effective and selective agents for scavenging metal oxo cations. A new approach involving the positioning of hydrogen atoms on the complexing agent in such a way as to bind to the oxo group associated with the metal will be tried. The research has implications for separation methodology, including that for members of the lanthanide and actinide families which are found in radioactive waste.