Specific Complexation of Metal Oxo Cations

该奖项为加州大学伯克利分校化学系的Kenneth N. Raymond博士对氧化金属阳离子选择性结合的研究提供了持续的支持。阳离子的形状选择性配体如锇酰和钒酰将被开发。这些配体将被设计成通过正常的配位结合稳定高氧化态金属中心，同时结合氢键供体与氧化阳离子相互作用。初步结果表明，如果精心定向，可以开发出刚性配体，氢键相互作用可以显着。要研究的配体包括氨基羧酸、儿茶酚酰胺、儿茶酚酚和酰胺类。所得化合物将通过晶体结构分析、振动光谱学、电化学和溶液热力学研究进行表征。将测试配体的特异性和络合能力。该项目的目标是开发有效的、选择性的金属氧化阳离子清除剂。将尝试一种新的方法，将氢原子定位在络合剂上，使其与与金属有关的氧基结合。这项研究对分离方法有影响，包括在放射性废物中发现的镧系元素和锕系元素的分离方法。

This award provides continuing support for the study of selective binding of oxo metal cations by Dr. Kenneth N. Raymond of the Department of Chemistry, University of California, Berkeley. Shape selective ligands for cations such as osmyl and vanadyl will be developed. These ligands will be designed to stabilize the high oxidation state metal center through normal coordinate binding, while at the same time incorporating hydrogen bond donors for interaction with the oxo cation. Preliminary results show that the hydrogen bonding interaction can be significant if carefully oriented, rigid ligands can be developed. Ligands to be investigated include aminocarboxylates, catechol amides, catechol phenols and amidates. The resulting compounds will be characterized by crystal structure analysis, vibrational spectroscopy, electrochemistry, and solution thermodynamics studies. Both the specificity and complexing ability of the ligands will be tested. %%% The goal of this project is to develop effective and selective agents for scavenging metal oxo cations. A new approach involving the positioning of hydrogen atoms on the complexing agent in such a way as to bind to the oxo group associated with the metal will be tried. The research has implications for separation methodology, including that for members of the lanthanide and actinide families which are found in radioactive waste.