Investigating resident macrophages in the leukemic bone marrow niche by probing the CD82-DARC axis

通过探测 CD82-DARC 轴来研究白血病骨髓生态位中的常驻巨噬细胞

• 批准号: 466959
• 负责人: Wilson Alannah K
• 金额: $ 1.27万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-12-01 至 2022-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=466959&lang=en
• 关键词: 3d Cell Culture; Bone Marrow Niche; Chemotherapy; Hematopoietic Stem Cell; Leukaemia; Leukemic Niche; Microenvironment; Monoclonal Antibody; Preclinical Animal Model; Resident Macrophage

The bone marrows (BM) main job is to produce the blood cells of our immune system in a process called hematopoiesis. In leukemia, the BM becomes filled with cancerous blood cells, which prevents normal hematopoiesis. Healthy BM contains various types of s

骨髓（BM）的主要工作是在称为造血的过程中产生我们免疫系统的血细胞。在白血病中，BM充满了癌性血细胞，从而阻止正常的造血。健康的BM包含各种类型的S